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93-55-0 Usage


Propiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.


In perfumery; in the synthesis of ephedrine and related Compounds.


Reported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.


https://en.wikipedia.org/wiki/Propiophenone https://pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top http://www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm https://www.alfa.com/en/catalog/A15140/


ChEBI: An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.

Chemical Properties

Propiophenone has a strong, flowery odor.


Intermediates of Liquid Crystals


Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.

Production Methods

Propiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.

Chemical Properties

colourless to light yellow liquid

Safety Profile

Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 2430, 1995 DOI: 10.1021/jo00113a024Tetrahedron Letters, 30, p. 4819, 1989 DOI: 10.1016/S0040-4039(01)80517-7



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name propiophenone

1.2 Other means of identification

Product number -
Other names phenyl-1-propanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:93-55-0 SDS