93-55-0

Basic information

• Product Name: Propiophenone
• Synonyms: 1-phenyl-1-propanon;1-phenyl-propan-1-one;1-phenylpropanone;1-phenylpropanone-1;1-Propanone,1-phenyl-;Ketone, ethyl phenyl;ketone,ethylphenyl;lithylphenyllwton
• CAS NO: 93-55-0
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• EINECS: 202-257-6
• Product Categories: Organics;API intermediates;Building Blocks;C9;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks;ketone;Purines
• Mol File: 93-55-0.mol
• Article Data: 903

Chemical Properties

• Melting Point: 17-19 °C(lit.)
• Boiling Point: 218 °C(lit.)
• Flash Point: 190 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.009 g/mL at 25 °C(lit.)
• Vapor Pressure: 1 mm Hg ( 50 °C)
• Refractive Index: n20/D 1.526(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: Difficult to mix.
• Water Solubility: INSOLUBLE
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
• Merck: 14,7830
• BRN: 606215
• CAS DataBase Reference: Propiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: Propiophenone(93-55-0)
• EPA Substance Registry System: Propiophenone(93-55-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: UG7175000
• TSCA: Yes
• Hazardous Substances Data: 93-55-0(Hazardous Substances Data)

Usage

Chemical Description

Propiophenone is a ketone with the chemical formula C9H10O.

Description

Propiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.

References

https://en.wikipedia.org/wiki/Propiophenone https://pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top http://www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm https://www.alfa.com/en/catalog/A15140/

Chemical Properties

Different sources of media describe the Chemical Properties of 93-55-0 differently. You can refer to the following data:
1. colourless to light yellow liquid
2. Propiophenone has a strong, flowery odor.

Occurrence

Reported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.

Uses

Different sources of media describe the Uses of 93-55-0 differently. You can refer to the following data:
1. Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.
2. In perfumery; in the synthesis of ephedrine and related Compounds.
3. Intermediates of Liquid Crystals

Definition

ChEBI: An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.

Production Methods

Propiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 2430, 1995 DOI: 10.1021/jo00113a024Tetrahedron Letters, 30, p. 4819, 1989 DOI: 10.1016/S0040-4039(01)80517-7

Flammability and Explosibility

Notclassified

Safety Profile

Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

InChI:InChI=1/C9H10O/c1-2-9(10)8-6-4-3-5-7-8/h3-7H,2H2,1H3

Upstream product

• 110-86-1 pyridine 
• 93-54-9 1-Phenyl-1-propanol 
• 71-43-2 benzene 
• 79-15-2 N-bromoacetamide 
• 4747-13-1 α-methoxystyrene 
• 2674-04-6 diphenyl cadmium 
• 79-03-8 propionyl chloride 
• 134-71-4 rac-ephedrine hydrochloride 
• 557-20-0 diethylzinc 
• 98-88-4 benzoyl chloride 
• 802294-64-0 propionic acid 
• 65-85-0 benzoic acid 
• 123-62-6 propionic acid anhydride 
• 60-29-7 diethyl ether 

Downstream Products

• 2832-98-6 3-morpholino-1-phenyl-3-thioxo-1-propanone 
• 86123-43-5 benzoic acid-(1-phenyl-2-[4]pyridyl-propenyl ester) 
• 57644-93-6 1-(1-methyl-2-oxo-2-phenyl-ethyl)-pyridinium; iodide 
• 52100-47-7 α-ethyl-α-phenyl-2-pyridinemethanol 
• 107552-41-0 NSC-42813 
• 195371-52-9 Z₃ 
• 112949-12-9 2-methyl-1-phenyl-4-[4]pyridyl-butan-1-one 
• 113058-58-5 2-methyl-1-phenyl-4-[4]pyridyl-2-(2-[4]pyridyl-ethyl)-butan-1-one 
• 103041-64-1 2-methyl-isonicotinic acid-(1-phenyl-propylidenehydrazide) 
• 330834-94-1 6-bromo-3-methyl-2-phenylquinoline-4-carboxylic acid 
• 39623-95-5 1-phenylprop-1-enyl acetate 
• 859954-86-2 1,4-bis-(1-chloro-2-methyl-3-oxo-3-phenyl-propyl)-benzene 
• 108981-28-8 (E)-2,3-diphenylpent-2-enenitrile 
• 108981-28-8 2,3-diphenyl-pent-2t-enenitrile 

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