Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production
A series of analogs based on a prototype aryl aminothiazole γ-secretase modulator (GSM) were synthesized and tested for their effects on the profile of 37-to-42-residue amyloid β-peptides (Aβ), generated through processive proteolysis of precursor protein
Bhattarai, Sanjay,Liu, Lei,Wolfe, Michael S.
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(2021/11/16)
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