137968-28-6

Basic information

• Product Name: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine
• Synonyms: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine;1H-pyrazol-5-amine, 1-[(4-fluorophenyl)methyl]-;[2-(4-fluorobenzyl)pyrazol-3-yl]amine;2-[(4-fluorophenyl)methyl]-3-pyrazolamine;2-[(4-fluorophenyl)methyl]pyrazol-3-amine
• CAS NO: 137968-28-6
• Molecular Formula: C₁₀H₁₀FN₃
• Molecular Weight: 191.2049032
• Mol File: 137968-28-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine(137968-28-6)
• EPA Substance Registry System: 1-(4-fluorobenzyl)-1H-pyrazol-5-amine(137968-28-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 137968-28-6(Hazardous Substances Data)

Usage

Chemical class

Pyrazole derivatives

Molecular weight

193.20 g/mol

Structure

Contains a pyrazole ring with a fluoro-substituted benzyl group

Applications

Pharmaceutical research and drug development

Potential therapeutic indications

Anti-inflammatory, anti-cancer, or anti-microbial agents

Pharmacological properties

Unique due to the presence of a fluoro-substituted benzyl group

Further research

Needed to fully understand its biological activities and potential uses in medicine

Upstream product

• 137968-22-0 1-<(p-Fluorobenzyl)amino>pyrazole 
• 1820-80-0 3-aminopyrazole 

Relevant articles and documents

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

The effective treatment for dengue virus infection continues to be a challenge. We herein reported our continued SAR exploration on the spiropyrazolopyridone scaffold. Introducing different substituents at the 3?- or 5?-site of the pyrazolopyridone core or moving the benzyl chain to the adjacent nitrogen led to a significant loss of potency on DENV-2. While a narrow range of substitutions were tolerated at the para-position of the phenyl ring, di-substitution on the phenyl ring is beneficial for DENV-2 potency and has variable influences on DENV-3 potency depending on the exact compound. Among these molecules, compounds 22 (JMX0376) with 4-chloro-3-fluorobenzyl and 24 (JMX0395) with 2,4-bis(trifluoromethyl)benzyl showed the most potent and broadest inhibitory activities against DENV-1 to ?3 with nanomolar to low micromolar EC50 values.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

Rearrangement of N-(Alkylamino)azoles in Acid Media: A New Entry to C-Amino-N-substituted Azoles

A ring-opening / ring-closure mechanism for the thermal rearrangement of 1-(alkylamino)pyrazoles into 5-amino-1-alkylpyrazoles in acid medium has been established. 1-(Benzylamino)pyrazoles show a different reactivity, affording bis(5-amino-1-benzyl-4-pyrazolyl)phenylmethanes.The reaction was extended to 1-(alkylamino)indazoles but failed in the case of 1-(alkylamino)-1,2,4-triazoles.