1820-80-0 Usage
Chemical Properties
3-Aminopyrazole is Low-Melting Yellow Solid
Uses
Different sources of media describe the Uses of 1820-80-0 differently. You can refer to the following data:
1. Employed in a one-pot synthesis of pyrazolopyrimidines.1
2. 3-Aminopyrazole was used in the spectroscopic characterization of ferrocenoyl peptides via 1H-NMR spectroscopy. It was also used in the synthesis of:symmetrical dialkylpyrazolo[1,5-a]pyrimidines via condensation with symmetrical β-diketones3,4-annelated coumarinsheterocyclic compounds of pharmaceutical interestpyrazolopyrimidines
3. 3-Aminopyrazole is used in the preparation of heterocyclic compounds of pharamaceutical interest
General Description
3-Aminopyrazole is a heteroarylamine.
Synthesis
The synthesis of?3-Aminopyrazole is as follows:A solution of 50 mg (0.34 mmol) of 3-oxo-3-phenylpropanenitrile and 11.6 mg (0.36 mmol) of hydrazine and 0.024 mL of acetic acid (0.37 mmol) in 3 mL of anhydrous ethanol was heated at 60° C for 24 hr. The mixture was cooled to ambient temperature and the solvent removed in vacuo. The residue was taken up in ethyl acetate, washed with saturated sodium bicarbonate. The organic layer was washed with brine and dried over MgSO4, filtered and evaporated. The solid residue waswashedwithethyl ether and dried in vacuo to give 45 mg (82%) of 3-phenyl-1H-pyrazol-5-amine.
Check Digit Verification of cas no
The CAS Registry Mumber 1820-80-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,2 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1820-80:
(6*1)+(5*8)+(4*2)+(3*0)+(2*8)+(1*0)=70
70 % 10 = 0
So 1820-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H5N3/c4-3-1-2-5-6-3/h1-2H,(H3,4,5,6)
1820-80-0Relevant articles and documents
Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy
Rana, Sandeep,Sonawane, Yogesh A.,Taylor, Margaret A.,Kizhake, Smitha,Zahid, Muhammad,Natarajan, Amarnath
supporting information, p. 3736 - 3740 (2018/10/24)
We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.
Rapid reduction of heteroaromatic nitro groups using catalytic transfer hydrogenation with microwave heating
Quinn, John F.,Bryant, Cole E.,Golden, Kathryn C.,Gregg, Brian T.
experimental part, p. 786 - 789 (2010/03/24)
A method for the rapid, safe reduction of heteroaromatic and aromatic nitro groups to amines is described using catalytic transfer hydrogenation under microwave heating conditions. Commonly available Pd/C or Pt/C catalyst is extremely effective with 1,4-cyclohexadiene as the hydrogen transfer source. In the case of substrates containing potentially labile aromatic halogens, Pt/C is effective and results in little or no dehalogenation. In general, the reactions are complete within 5 min at 120 °C.
Methods of treating cytokine mediated diseases
-
, (2008/06/13)
Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein.
