The synthesis and structure-activity relationship of 4-benzimidazolyl- piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists
A structure-activity relationship study of the lead piperazinylcarbonylpiperidine compound 3 resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine 6h as a histamine-3 (H 3) receptor antagonist. Additional optimizatio
Ting, Pauline C.,Lee, Joe F.,Albanese, Margaret M.,Wu, Jie,Aslanian, Robert,Favreau, Leonard,Nardo, Cymbelene,Korfmacher, Walter A.,West, Robert E.,Williams, Shirley M.,Anthes, John C.,Rivelli, Maria A.,Corboz, Michel R.,Hey, John A.
scheme or table
p. 5004 - 5008
(2010/10/05)
PIPERIDINE DERIVATIVES AND METHODS OF USE THEREOF
The present invention relates to Compounds of Formula (I), compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) in a patient.
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Page/Page column 33-34
(2008/12/08)
1-(4-PIPERIDINYL) BENZIMIDAZOLONES AS HISTAMINE H3 ANTAGONISTS
Disclosed are histamine H3 antagonists of the formula (I) wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined
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Page 18
(2010/02/04)
Reductive amination of piperidines with aldehydes using borane-pyridine
Borane-pyridine complex (BAP) was found to be an excellent replacement for NaCNBH3 in the Borch reduction. Assorted aromatic, heterocyclic and aliphatic aldehydes were reacted with various substituted piperidines using standardized conditions.
Moormann
p. 789 - 795
(2007/10/02)
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