- TRANS-CYCLOOCTENE LABELED ANTISENSE OLIGONUCLEOTIDES, RADIO LABELED TETRAZINE AND METHODS
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Featured are trans-cyclooctene and tetrazine compounds. Also provided are methods for evaluating the biodistribution and/or concentration of a biomolecule in a subject.
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Page/Page column 46-47
(2021/02/26)
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- Metal-Free Synthetic Approach to 3-Monosubstituted Unsymmetrical 1,2,4,5-Tetrazines Useful for Bioorthogonal Reactions
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A facile, efficient and metal-free synthetic approach to 3-monosubstituted unsymmetrical 1,2,4,5-tetrazines is presented. Dichloromethane (DCM) is for the first time recognized as a novel reagent in the synthetic chemistry of tetrazines. Using this novel approach 11 3-aryl/alkyl 1,2,4,5-tetrazines were prepared in excellent yields (up to 75 %). The mechanism of this new reaction, including the role of DCM in the tetrazine ring formation, has been investigated by 13C labeling of DCM, and is also presented and discussed as well as the photophysical and electrochemical properties.
- Qu, Yangyang,Sauvage, Fran?ois-Xavier,Clavier, Gilles,Miomandre, Fabien,Audebert, Pierre
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supporting information
p. 12057 - 12061
(2018/09/06)
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- NOVEL TETRAZINES AND METHOD OF SYNTHESIZING THE SAME
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Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines and diazonorcaradienes.
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Paragraph 0293
(2013/10/22)
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- Metal-catalyzed one-pot synthesis of tetrazines directly from aliphatic nitriles and hydrazine
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Paving the way: The lack of convenient synthetic methods is a significant roadblock to the broader use of 1,2,4,5-tetrazines in bioorthogonal chemistry and functional materials. Lewis acid metal catalysts-most notably divalent nickel and zinc salts-are described to catalyze the one-pot synthesis of 1,2,4,5-tetrazines directly from aliphatic nitriles (see scheme). Copyright
- Yang, Jun,Karver, Mark R.,Li, Weilong,Sahu, Swagat,Devaraj, Neal K.
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supporting information; experimental part
p. 5222 - 5225
(2012/07/14)
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