- Sustainable and cost-efficient electro-synthesis of formamidine acetate from cyanamide in aqueous acidic electrolyte
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Formamidine represents a versatile building block in synthetic organic chemistry. We developed a new electrochemical synthesis of formamidine acetate by cathodic reduction of cyanamide in an aqueous electrolyte and in high yield. The crude product could be used for further conversions, such as to pyrimidines without purification. Compared to established synthetic routes neither prior processing of cyanamide was necessary, nor precious transition-metal catalyst were required, nor any reagent waste was produced, and only biocompatible and sustainable solvents were employed for this process, following the requirements ofgreen chemistry.
- Güthner, Thomas,Klein, Martin,Sans, Jürgen,Thalhammer, Franz,Waldvogel, Siegfried R.
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supporting information
p. 3289 - 3294
(2021/05/25)
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- Method for producing formamidine acetate
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PROBLEM TO BE SOLVED: To provide a means for producing high-purity formamidine acetate in high yield according to an economical and simple method. SOLUTION: When the formamidine acetate is produced by reacting a trialkyl orthoformate with acetic acid and ammonia, the reaction is advanced under refluxing conditions. COPYRIGHT: (C)2010,JPOandINPIT
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Sheet 0056; 0057
(2018/10/24)
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- SIMPLE AMIDINIUM CARBOXYLATES - AN MO TREATMENT OF MOLECULAR GEOMETRY AND ELECTRONIC STRUCTURE
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Carboxylates of amidines (I,II), substituted guanidine (III) and iso(thio)ureas (IV,V) were prepared.Nonempirical quantum chemical treatment of the electronic structure of simple compounds I-V, based on total molecular geometry optimization, their preparation and physicochemical data are reported.Interaction between the two amidinium nitrogens and carboxylate oxygens is mediated by hydrogen bonds and alternation of charge distribution.
- Krechl, Jiri,Boehm, Stanislav,Smrckova, Svatava,Kuthan, Josef
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p. 673 - 683
(2007/10/02)
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