- Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases
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Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009-0.0015 μM) from a
- Schonbrunn, Ernst,Betzi, Stephane,Alam, Riazul,Martin, Mathew P.,Becker, Andreas,Han, Huijong,Francis, Rawle,Chakrasali, Ramappa,Jakkaraj, Sudhakar,Kazi, Aslamuzzaman,Sebti, Said M.,Cubitt, Christopher L.,Gebhard, Anthony W.,Hazlehurst, Lori A.,Tash, Joseph S.,Georg, Gunda I.
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p. 3768 - 3782
(2013/06/27)
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- Use of 2,4-diaminothiazole derivatives
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2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.
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