- Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives
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A series of novel podophyllotoxin derivatives containing structural modifications at C-4 (7-14), C-4′ (16-17), and the methylenedioxy A-ring (23-28) was synthesized and tested for inhibition of HIV replication. Four of these compounds (25-28) were previou
- Zhu, Xiao-Kang,Guan, Jian,Xiao, Zhiyan,Cosentino, L. Mark,Lee, Kuo-Hsiung
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p. 4267 - 4273
(2007/10/03)
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- Antitumor agents. 124. New 4β-substituted aniline derivatives of 6,7-O,O- demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
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A series of 6,7-O,O-demethylene-4'-O-demethyl-4β-(substituted anilino)-4- desoxypodophyllotoxins (18-23), 6,7-O,O-demethylene-6,7-O,O-dimethyl-4'-O- demethyl-4β-(substituted anilino)-4-desoxypodophyllotoxins (28-31), and their corresponding 4'-O-methyl an
- Wang,Hu,Chen,Cheng,Lee
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p. 871 - 877
(2007/10/02)
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