138485-30-0

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER
• Synonyms: 2-(4-FLUOROPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER
• CAS NO: 138485-30-0
• Molecular Formula: C₁₁H₁₁FO₄
• Molecular Weight: 226.202
• Mol File: 138485-30-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER(138485-30-0)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER(138485-30-0)

Safety Data

• Hazardous Substances Data: 138485-30-0(Hazardous Substances Data)

Usage

Compound class

Fluoroaromatic compounds

Physical state

Colorless liquid

Derivation

Combination of 4-fluorophenyl and propanedioic acid

Usage

Chemical research, building block for synthesis of complex organic compounds

Industrial applications

Unique chemical properties

Safety precautions

Handle with care and follow safety guidelines due to potential hazards when mishandled.

Upstream product

• 553-90-2 Dimethyl oxalate 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 1401354-92-4 C₂₄H₂₆FNO₃ 
• 1401355-04-1 C₂₄H₂₆FNO₃ 
• 1401354-80-0 α-tert-butoxycarbonyl-α-(4-fluorophenyl)-γ-methylidene-δ-valerolactone 
• 138485-62-8 3-(4-Fluoro-phenyl)-4-hydroxy-6-methyl-1H-pyridin-2-one 
• 145983-06-8 α-(p-fluorophenyl)-α-methylmalonic acid 
• 150360-26-2 (2R)-2-(4-fluorophenyl)propanoic acid 
• 138485-35-5 5-(4-Fluoro-phenyl)-4-hydroxy-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Gold(I)-Catalyzed Enantioselective Desymmetrization of 1,3-Diols through Intramolecular Hydroalkoxylation of Allenes

A gold(I)-catalyzed enantioselective desymmetrization of 1,3-diols was achieved by intramolecular hydroalkoxylation of allenes. The catalyst system 3-F-dppe(AuCl)2 /(R)-C8-TRIPAg proved to be specifically efficient to promote the desymmetrizing cyclization of 2-aryl-1,3-diols, which have proven challenging substrates in previous reports. Multisubstituted tetrahydrofurans were prepared in good yield with good enantioselectivity and diastereoselectivity by this method.

Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter

A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of γ-methylidene-δ-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand. The Royal Society of Chemistry 2012.

Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids.Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing.Decarboxylation of α-fluoro-α-phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro-α-phenylacetic acid.

Anti-mycobacterial 4-hydroxy-3-phenylpyridin-2(1H)-ones

4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl β-aminocrotonates with dialkyl malonates or 'magic malonates' (2,4,6-trichlorophenyl malonates).The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, MIC=8μg/ml).A structure-activity relationship is discussed.