150360-26-2

Basic information

• Product Name: (2R)-2-(4-fluorophenyl)propanoic acid
• Synonyms: (2R)-2-(4-fluorophenyl)propanoic acid
• CAS NO: 150360-26-2
• Molecular Weight: 168.168
• EINECS: -0
• Mol File: 150360-26-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (2R)-2-(4-fluorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(4-fluorophenyl)propanoic acid(150360-26-2)
• EPA Substance Registry System: (2R)-2-(4-fluorophenyl)propanoic acid(150360-26-2)

Safety Data

• Hazardous Substances Data: 150360-26-2(Hazardous Substances Data)

Usage

General Description

The chemical compound (2R)-2-(4-fluorophenyl)propanoic acid is a derivative of propanoic acid with a 4-fluorophenyl group attached to the second carbon atom. It is a chiral compound with a specific 2R configuration. (2R)-2-(4-fluorophenyl)propanoic acid has potential applications in pharmaceuticals as it may have anti-inflammatory and analgesic properties. It is also used as a building block in the synthesis of various organic compounds. The presence of the fluorine atom in its structure makes it a useful tool in fluorine chemistry and as a starting material for the synthesis of fluorinated compounds. Overall, (2R)-2-(4-fluorophenyl)propanoic acid is a versatile compound with various potential applications in the fields of pharmaceuticals and organic synthesis.

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 350-40-3 2-(4-fluorophenyl)-1-propene 
• 947383-48-4 (E)-1-fluoro-4-(1-nitroprop-1-en-2-yl)benzene 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 64-18-6 formic acid 
• 549532-50-5 2-(4-fluorophenyl)propanal 
• 405-99-2 para-fluorostyrene 
• 459-22-3 4-fluorophenylacetonitrile 
• 75908-73-5 (+/-)-2-(4-flurophenyl)propanoic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 50415-71-9 methyl 2-(4-fluorophenyl)propanoate 
• 138485-30-0 2-(4-Fluoro-phenyl)-malonic acid dimethyl ester 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 459-04-1 4-Fluorophenylacetyl chloride 

Downstream Products

• 1443763-60-7 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide 
• 1443763-62-9 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]propanamide 
• 1443763-63-0 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide 
• 1443763-64-1 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxybenzamide 
• 1443763-65-2 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-(2,2,2-trifluoroethoxy)benzamide 
• 1443763-66-3 (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide 
• 1443763-67-4 (2R)-N-[4-(2-{[4-(azetidin-1-ylcarbonyl)-2-methoxyphenyl]amino}[1,2,4]-triazolo[1,5-α]pyridin-6-yl)phenyl]-2-(4-fluorophenyl)propanamide 
• 1443763-68-5 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(2-oxo-1,3-oxazolidin-3-yl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide 
• 1443763-71-0 (2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide 
• 374898-01-8 (R)-1-(4-fluorophenyl)ethylamine 
• 1443763-72-1 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N,N-dimethylbenzamide 
• 1443763-74-3 (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-(2,2,2-trifluoroethoxy)phenyl}amino)[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide 

Relevant articles and documents

Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens

We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.

Substrate Scope Evaluation of the Enantioselective Reduction of β-Alkyl-β-arylnitroalkenes by Old Yellow Enzymes 1-3 for Organic Synthesis Applications

The substrate scope of the old yellow enzyme catalyzed reduction of β-alkyl-β-arylnitroalkenes is investigated. Compounds bearing either alkyl chains of increasing length at the carbon atom in position β to the nitro group or different substituents on the aromatic ring are prepared and submitted to bioreduction, to define the synthetic potential of this enantioselective reaction in the preparation of chiral fine chemicals. The versatility of the resulting nitroalkanes as chiral building blocks is shown by reducing the nitro group into a primary amine and by converting it into a carboxylic acid moiety by Meyer reaction. An "explosion" of chiral products can be observed by combining the highly enantioselective ene-reductase-mediated reduction of nitroalkenes with the chemical versatility of the nitro group.

METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.