- New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6′R)-6′-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor
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An improved method for the synthesis of (6′R)-6′-C-methylneplanocin A (RMNPA, 2), a potent S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitor, was developed via a chelation-controlled stereoselective addition of MeTiCl3 to the neplanocin A
- Shuto, Satoshi,Minakawa, Noriaki,Niizuma, Satoshi,Kim, Hye-Sook,Wataya, Yusuke,Matsuda, Akira
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p. 748 - 751
(2007/10/03)
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- New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents
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Novel neplanocin A analogues modified at the 6'-position, i.e., 6'-deoxy analogues (2, 3, 6, 9, 20), 6'-O-methylneplanocin A (15), and 6'-C- methylneplanocin A's (22a and 22b) have been synthesized and evaluated for their antiviral activity in a wide vari
- Shuto,Obara,Toriya,Hosoya,Snoeck,Andrei,Balzarini,De Clercq
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p. 324 - 331
(2007/10/02)
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