138642-97-4

Basic information

• Product Name: IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-chloro-
• Synonyms: IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-chloro-;6-ChloroiMidazo[1,2-a]pyridine-3-carboxylic acid hydrate, 95%
• CAS NO: 138642-97-4
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.5905
• Mol File: 138642-97-4.mol

Chemical Properties

• Appearance: /
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-chloro-(138642-97-4)
• EPA Substance Registry System: IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-chloro-(138642-97-4)

Safety Data

• Hazardous Substances Data: 138642-97-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-chlorois used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its chemical structure allows for further functionalization and modification, making it a versatile building block in the development of new drugs with potential applications in treating different medical conditions.
As a pharmaceutical intermediate, Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-chloroplays a crucial role in the synthesis of various drug candidates. Its unique chemical properties enable the creation of novel compounds with improved pharmacological profiles, such as enhanced potency, selectivity, and bioavailability. This makes it a valuable asset in the ongoing efforts to discover and develop new medications for a wide range of diseases and disorders.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 

Relevant articles and documents

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

A 6-chloro imidazo [1, 2-a] pyridine-3-carboxylic acid synthesis method

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of 6-chloroimidazo[1,2-alpha]pyridyl-3-formic acid. The method comprises the following steps: reacting N,N-dimethylformamidodimethyl acetal with 2-amino-5-chloropyridine at 40-100 DEG C for 2-8 hours to obtain an intermediate, reacting the intermediate with ethyl chloroacetate at 60-160 DEG C for 3-15 hours under the action of an alkali, concentrating by rotary evaporation to obtain an ethyl 6-chloroimidazo[1,2-alpha]pyridyl-3-formate crude product, and recrystallizing the crude product to obtain a pure product; and carrying out hydrolysis reaction in a certain solvent under the action of an alkali for 1-5 hours, neutralizing with hydrochloric acid, filtering, washing with water, and drying to directly obtain the 6-chloroimidazo[1,2-alpha]pyridyl-3-formic acid pure product. The method has the advantages of accessible reaction raw materials, reasonable price, mild reaction conditions and simple after-treatment, and is easy to operate and control; and the product has the advantages of stable quality and high purity.