1072-98-6

Basic information

• Product Name: 2-Amino-5-chloropyridine
• Synonyms: 2-Amino-5-chloropyridine 2-Amino-5-chloropyridine;2-AMINO-5-CHLOROPYRIDINE 5-CHLORO-PYRIDIN-2-YLAMINE;5-Chloro-2-pyridineamine;5-Chloro-a-aminopyridine;2-Amino-5-chloropyridine ,98%;2-Amino-5-chlorophridine;2-AMINO-5-CHLOROPYRIDINE FOR SYNTHESIS
• CAS NO: 1072-98-6
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• EINECS: 214-020-4
• Product Categories: Bromides;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivates;Chloropyridines;Halopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series;amine| alkyl chloride;PYRIDINE;Nitrogen cyclic compounds;FINE Chemical & INTERMEDIATES;Amines;blocks
• Mol File: 1072-98-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 135-138 °C(lit.)
• Boiling Point: 127-128 °C11 mm Hg(lit.)
• Flash Point: 160 °C
• Appearance: Beige to beige-brown/Crystalline Powder
• Density: 1.2417 (rough estimate)
• Vapor Pressure: 0.0142mmHg at 25°C
• Refractive Index: 1.5110 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 1.0g/l
• PKA: 4.67±0.13(Predicted)
• Water Solubility: 1 g/L (20 ºC)
• BRN: 108735
• CAS DataBase Reference: 2-Amino-5-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-chloropyridine(1072-98-6)
• EPA Substance Registry System: 2-Amino-5-chloropyridine(1072-98-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 22-24/25-37/39-26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1072-98-6(Hazardous Substances Data)

Usage

Chemical Properties

beige to beige-brown crystalline powder

Uses

5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020

Purification Methods

Recrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]

InChI:InChI=1/C5H5ClN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)/p+1

Synthetic route

2-aminopyridine (504-29-0) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With N-chloro-N-fluoro-benzenesulfonamide; 1,3-dimethylimidazolium chloride In dichloromethane at 25℃; for 1.5h; Reagent/catalyst; Concentration; Solvent; Temperature;	99%
With bromine; chlorine In acetonitrile for 2h; Solvent; UV-irradiation;	99.4%
With N-ethylpyridinium chloride aluminum trichloride; chlorine In acetonitrile for 0.833333h; Solvent; Reagent/catalyst; Microwave irradiation;	99.4%

2,2-dimethyl-3-(5-chloropyrid-2-yl)-4-4H-1,3-benzoxazine (74405-03-1) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With hydrogenchloride for 8h; Heating;	95%

N-(3-bromo-5-chloropyridin-2-yl)pyridin-1-ium-1-aminide (171774-38-2) → 5-chloro-2-pyridylamine (1072-98-6) + 3-chloro-dipyrido[1,2-b;3',2'-d]pyrazole

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In acetonitrile; benzene at 80℃; for 24h;	A 90% B 2%
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; potassium carbonate In acetonitrile; benzene at 80℃; for 24h; Product distribution; Further Variations:; Reagents;	A 5% B 56%

pent-4-ynenitrile (19596-07-7) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With iron(III) chloride; chlorine; sodium hydroxide In chloroform; water at 40 - 45℃; for 5h; Solvent; Inert atmosphere;	89.1%

C10H7ClIN3 → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With triethylammonium formate; platinum on activated charcoal In acetonitrile for 4h; Heating;	87%

2-fluoro-5-chloropyridine (1480-65-5) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;	84%

5-chloro-2-nitropyridine (52092-47-4) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With sulfuric acid; hydrogen In ethanol at 25℃; Electrochemical reaction;	82%
With boron dimethyl-trifluoro sulphide In dichloromethane at 60℃; for 0.5h; Sealed tube;	72%
With hydrogenchloride; sodium hydrogensulfide
With hydrogenchloride; tin(ll) chloride
With ammonium hydroxide; iron(II) sulfate

pyridinium N-(5'-chloropyridin-2'-yl)aminide (172617-53-7) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With zinc In acetic acid for 29h; Ambient temperature;	79%

propanal (5-chloropyridin-2-yl)hydrazone → 5-chloro-2-pyridylamine (1072-98-6) + 5-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine (1256803-09-4)

Conditions	Yield
With polyphosphoric acid at 160 - 180℃; for 0.0833333h; Fischer Indole Synthesis;	A 72% B 6%

2-aminopyridine (504-29-0) → 5-chloro-2-pyridylamine (1072-98-6) + 2-amino-3-chloropyridine (39620-04-7)

Conditions	Yield
With hydrogenchloride; sodium hypochlorite at 10 - 25℃; for 6h; Overall yield = 5.82 g;	A 71.6% B n/a

1-benzylpiperidin-4-one (5-chloropyridin-2-yl)hydrazone → 5-chloro-2-pyridylamine (1072-98-6) + 6-benzyl-3-chloro-6,7,8,9-tetrahydro-5H-pyrido-[3',4':4,5]pyrrolo[2,3-b]pyridine

Conditions	Yield
With polyphosphoric acid for 14h; Fischer Indole Synthesis; Inert atmosphere; Heating;	A 30% B 49%

phenylethanal (5-chloropyridin-2-yl)hydrazone → 5-chloro-2-pyridylamine (1072-98-6) + 5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine

Conditions	Yield
With polyphosphoric acid at 160 - 180℃; for 0.0833333h; Fischer Indole Synthesis;	A 40% B 28%

1-methylpiperidin-4-one (5-chloropyridin-2-yl)hydrazone → 5-chloro-2-pyridylamine (1072-98-6) + 3-chloro-6-methyl-6,7,8,9-tetrahydro-5H-pyrido-[3',4':4,5]pyrrolo[2,3-b]pyridine (1394062-37-3)

Conditions	Yield
With polyphosphoric acid for 14h; Fischer Indole Synthesis; Inert atmosphere; Heating;	A 29% B 36%

butanal (5-chloropyridin-2-yl)hydrazone → 5-chloro-2-pyridylamine (1072-98-6) + 5-chloro-3-ethyl-1H-pyrrolo[2,3-b]pyridine

Conditions	Yield
With polyphosphoric acid at 160 - 180℃; for 0.0833333h; Fischer Indole Synthesis;	A 36% B 25%

2-aminopyridine (504-29-0) → 5-chloro-2-pyridylamine (1072-98-6) + 3,5-dichloropyridin-2-amine (4214-74-8)

Conditions	Yield
With chloroform; chlorine
With chlorine; acetic acid
With chloroform; chlorine; acetic acid

2-aminopyridine (504-29-0) + ethanol (64-17-5) + chlorine (7782-50-5) → 5-chloro-2-pyridylamine (1072-98-6)

2-aminopyridine (504-29-0) + chloroform (67-66-3) + chlorine (7782-50-5) → 5-chloro-2-pyridylamine (1072-98-6)

2-aminopyridine (504-29-0) + chlorine (7782-50-5) + acetic acid (64-19-7) → 5-chloro-2-pyridylamine (1072-98-6)

diazotized 2.5-diamino-pyridine → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With copper(l) chloride

6-amino-pyridine-3-diazonium ; chloride + copper (I)-chloride → 5-chloro-2-pyridylamine (1072-98-6)

3-chloropyridine-N-oxide (1851-22-5) → 5-chloro-2-pyridylamine (1072-98-6) + potassium nitrite

Conditions	Yield
Multi-step reaction with 2 steps 1: 68 percent / CHCl3 / 4 h / Heating 2: 95 percent / conc. HCl / 8 h / Heating View Scheme

3-hydroxy-2-nitropyridine (15128-82-2) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
Multi-step reaction with 5 steps 1: acetic acid anhydride; nitric acid 2: phosphorus (V)-chloride / 130 °C 3: methanol; N2H4 4: silver acetate; water 5: FeSO4; aqueous NH3 View Scheme
Multi-step reaction with 5 steps 1: acetic acid; acetic acid anhydride; nitric acid 2: phosphorus (V)-chloride / 130 °C 3: methanol; N2H4 4: silver acetate; water 5: FeSO4; aqueous NH3 View Scheme

(3-chloro-6-nitro-[2]pyridyl)-hydrazine (99848-04-1) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: silver acetate; water 2: FeSO4; aqueous NH3 View Scheme

3-hydroxy-2,6-dinitropyridine (15128-91-3) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
Multi-step reaction with 4 steps 1: phosphorus (V)-chloride / 130 °C 2: methanol; N2H4 3: silver acetate; water 4: FeSO4; aqueous NH3 View Scheme

3-chloro-2,6-dinitro-pyridine (101079-67-8) → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: methanol; N2H4 2: silver acetate; water 3: FeSO4; aqueous NH3 View Scheme

2-aminopyridine (504-29-0) + concentrated sodium hydroxide → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
With hydrogenchloride; chlorine In water; Petroleum ether

5-chloro-N-formyl-N-(3-oxobutyl)-2-pyridylamine → 5-chloro-2-pyridylamine (1072-98-6) + methyl vinyl ketone (78-94-4)

Conditions	Yield
With ammonium acetate

N'-(5-chloropyridin-2-yl)-N,N-dimethylformimidamide → 5-chloro-2-pyridylamine (1072-98-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: water / 0.92 h / 140 °C / Microwave irradiation; Inert atmosphere; Sealed tube 2: ammonium acetate View Scheme

5-chloro-2-pyridylamine (1072-98-6) + pivaloyl chloride (3282-30-2) → N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide (86847-83-8)

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 1.08333h;	99%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1h;	97%

5-chloro-2-pyridylamine (1072-98-6) + 5-Chloroisatoic anhydride (4743-17-3) → (2-amino-5-chlorophenyl)-N-(5-chloro(2-pyridyl))carboxamide

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran; toluene	100%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	100%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	100%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	99%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	99%

5-chloro-2-pyridylamine (1072-98-6) + 2-(2-nitrophenyl)acetic acid (3740-52-1) → N-(5-chloropyridin-2-yl)-2-(2-nitrophenyl)acetamide (349124-95-4)

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	100%

5-chloro-2-pyridylamine (1072-98-6) + 5-Chloroisatoic anhydride (4743-17-3) → 2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide (229343-30-0)

Conditions	Yield
Stage #1: 5-chloro-2-pyridylamine With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 0.5h; Stage #2: 5-Chloroisatoic anhydride In tetrahydrofuran; toluene at -78 - 20℃;	100%
Stage #1: 5-chloro-2-pyridylamine With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 0.5h; Stage #2: 5-Chloroisatoic anhydride In tetrahydrofuran; toluene at -78 - 20℃;	99%
Stage #1: 5-chloro-2-pyridylamine With dmap; potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; Inert atmosphere; Stage #2: 5-Chloroisatoic anhydride In tetrahydrofuran; toluene at -78 - 20℃; for 10h; Inert atmosphere;

5-chloro-2-pyridylamine (1072-98-6) + 1,1,3-trichloroacetone (921-03-9) → 6-chloro-2-(dichloromethyl)-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrochloride

Conditions	Yield
In tetrahydrofuran at 20 - 70℃; for 16.5h;	100%

5-chloro-2-pyridylamine (1072-98-6) + 2-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-pyrido[3,4-d][1,3]oxazin-4-one (852370-52-6) → 3-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-4-carboxamide (852370-53-7)

Conditions	Yield
Stage #1: 5-chloro-2-pyridylamine; allylmagnesium bromide In tetrahydrofuran; diethyl ether at 0℃; for 0.0833333h; Stage #2: 2-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-pyrido[3,4-d][1,3]oxazin-4-one In tetrahydrofuran; diethyl ether at 0 - 20℃;	99%

5-chloro-2-pyridylamine (1072-98-6) + 2,3-pyrazinedicarboxylic anhydride (4744-50-7) → 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid (43200-83-5)

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	99%
In tetrahydrofuran at 20℃; for 1h;	99%
In dichloromethane at 5 - 20℃; for 3.5h; Product distribution / selectivity;
Stage #1: 5-chloro-2-pyridylamine; 2,3-pyrazinedicarboxylic anhydride In toluene at 20 - 52℃; for 2.5h; Stage #2: With hydrogenchloride In water at 10 - 15℃; for 1h;

tetrakis-pivaloyloxymethyl ester of vinylidene-1,1-bisphosphonate + 5-chloro-2-pyridylamine (1072-98-6) → tetrakispivaloyloxymethyl 2-(5-chloropyridine-2-ylamino)ethylidene-1,1-bisphosphonate

Conditions	Yield
In chloroform at 20℃; for 1h;	99%

5-chloro-2-pyridylamine (1072-98-6) + 2-phenoxy-1-phenylethanone (721-04-0) → 6-chloro-3-phenoxy-2-phenylimidazo[1,2-a]pyridine

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	99%

5-chloro-2-pyridylamine (1072-98-6) + 2-phenoxy-1-phenylethanone (721-04-0) → 3-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-6-bromoimidazo[1,2-a]pyridine

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	99%

5-chloro-2-pyridylamine (1072-98-6) + phenyl chloroformate (1885-14-9) → phenyl 5-chloropyridin-2-ylcarbamate (95651-20-0)

Conditions	Yield
With pyridine In dichloromethane for 2h; Cooling with ice;	98%
With pyridine at 20℃;

5-chloro-2-pyridylamine (1072-98-6) + N-(2-benzene-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide (98416-35-4) → N-{2,2-dichloro-1-[(5-chloro-2-pyridinyl)amino]-2-phenylethyl}-4-chlorobenzenesulfonamide (1435914-39-8)

Conditions	Yield
In 1,4-dioxane at 20℃; for 4h;	98%

5-chloro-2-pyridylamine (1072-98-6) + tert-butyl isocyanide (630-18-2) + benzaldehyde (100-52-7) → N-tert-butyl-6-chloro-2-phenylimidazo[1,2-a]pyridin-3-amine

Conditions	Yield
With praseodymium(III) chloride In ethanol at 60℃; for 1h; Temperature; Reagent/catalyst; Schlenk technique; Inert atmosphere;	98%

5-chloro-2-pyridylamine (1072-98-6) + 2-methoxy-pyridine-5-boronic acid (163105-89-3) → 5-(6-methoxypyridin-3-yl)pyridin-2-amine

Conditions	Yield
With potassium acetate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In water; butan-1-ol at 100℃; Suzuki-Miyaura cross-coupling;	97%

5-chloro-2-pyridylamine (1072-98-6) + 2-nitro-3-methoxybenzoyl chloride (15865-57-3) → N-(5-chloro-2-pyridinyl)-2-nitro-3-methoxyphenylcarboxamide (229342-58-9)

Conditions	Yield
With pyridine; dmap at 20℃;	97%

5-chloro-2-pyridylamine (1072-98-6) + 2-bromo-1-[3-nitro-4-(trifluoromethyl)phenyl]ethanone (1227600-76-1) → 6-chloro-2-[3-nitro-4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyridine (1383624-94-9)

Conditions	Yield
In acetonitrile at 100℃; for 18h;	97%

5-chloro-2-pyridylamine (1072-98-6) + N-(2-benzene-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide (98416-35-4) → N-(6-chloro-2-phenylimidazo[1,2-a]pyridine-3-yl)-4-chlorobenzenesulfonamide (1435914-48-9)

Conditions	Yield
Stage #1: 5-chloro-2-pyridylamine; N-(2-benzene-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide In 1,4-dioxane at 20℃; for 4h; Stage #2: With sodium hydroxide at 20℃; for 5h;	97%

5-chloro-2-pyridylamine (1072-98-6) + acetoacetic acid methyl ester (105-45-3) → 7-chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (64500-18-1)

Conditions	Yield
With bismuth(III) chloride at 100℃; for 3h; Green chemistry;	97%

5-chloro-2-pyridylamine (1072-98-6) + alpha-(3-methylphenoxy)acetophenone (19514-02-4) → 6-chloro-2-phenyl-3-(m-tolyloxy)imidazo[1,2-a]pyridine

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	97%

5-chloro-2-pyridylamine (1072-98-6) + allyl oxalyl chloride (74503-07-4) → 2-[(5-chloro-2-pyridyl)amino]-2-oxoacetic acid allyl ester hydrochloride

Conditions	Yield
In acetonitrile at 30 - 50℃;	96.5%

5-chloro-2-pyridylamine (1072-98-6) + 5-methoxy-2-nitro-benzoic acid (1882-69-5) → 5-methoxy-2-nitro-N-(5-chloro-pyridine-2-yl)benzamide (280773-16-2)

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 1h; Solvent; Temperature;	96.2%
With pyridine; trichlorophosphate In acetonitrile at 0 - 30℃; for 1h; Inert atmosphere;	94%
With pyridine; trichlorophosphate In acetonitrile at 19 - 28℃; for 1h;	88.2%

5-chloro-2-pyridylamine (1072-98-6) + 4-chlorobenzaldehyde (104-88-1) + phosphonic acid diethyl ester (762-04-9) → diethyl (79202-10-1)

Conditions	Yield
at 80 - 100℃;	96%

5-chloro-2-pyridylamine (1072-98-6) + p-toluenesulfonyl chloride (98-59-9) → N-[5-Chloro-1H-pyridin-(2Z)-ylidene]-4-methyl-benzenesulfonamide (54818-84-7)

Conditions	Yield
With pyridine at 80 - 90℃;	96%

5-chloro-2-pyridylamine (1072-98-6) + methyl 2-(4-bromophenyl)-2-diazoacetate (264881-99-4) → methyl 2-(4-bromophenyl)-2-((5-chloropyridin-2-yl)amino)acetate (1394824-05-5)

Conditions	Yield
at 102℃; for 12h; Inert atmosphere;	96%

5-chloro-2-pyridylamine (1072-98-6) + tert-butylisonitrile (119072-55-8, 7188-38-7) + 2-chloro-3-carbaldehydepyridine (36404-88-3) → N-tert-butyl-6-chloro-2-(2-chloropyridin-3-yl)imidazo[1,2-a]pyridin-3-amine

Conditions	Yield
With iodine In ethanol at 70℃; for 0.5h; Solvent; Temperature;	96%

5-chloro-2-pyridylamine (1072-98-6) + 2,2-dimethoxy-2-phenylethyl 4-methylbenzenesulfonate → 6-chloro-2-phenylimidazo[1,2-a]pyridine (168837-18-1)

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In acetonitrile at 120℃; for 24h;	96%

5-chloro-2-pyridylamine (1072-98-6) + C16H16O2 → 6-chloro-3-(4-ethylphenoxy)-2-phenylimidazo[1,2-a]pyridine

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	96%

5-chloro-2-pyridylamine (1072-98-6) + 4-chloro-benzoyl chloride (122-01-0) → 4-chloro-N-(5-chloropyridin-2-yl)benzamide

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h; Cooling;	96%

5-chloro-2-pyridylamine (1072-98-6) + 1-(hydroxymethyl)-1,2,4-triazole (74205-82-6) → (5-chloro-pyridin-2-yl)-[1,2,4]triazol-1-ylmethyl-amine

Conditions	Yield
In ethanol for 3h; Heating;	95.87%

Upstream product

• 74405-03-1 2,2-dimethyl-3-(5-chloropyrid-2-yl)-4-4H-1,3-benzoxazine 
• 504-29-0 2-aminopyridine 
• 1480-65-5 2-fluoro-5-chloropyridine 
• 19596-07-7 pent-4-ynenitrile 
• 27032-63-9 5-chloro-pyridin-2-yl hydrazine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 101079-67-8 3-chloro-2,6-dinitro-pyridine 
• 15128-91-3 3-hydroxy-2,6-dinitropyridine 
• 99848-04-1 (3-chloro-6-nitro-[2]pyridyl)-hydrazine 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 1851-22-5 3-chloropyridine-N-oxide 
• 171774-38-2 N-(3-bromo-5-chloropyridin-2-yl)pyridin-1-ium-1-aminide 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 

Downstream Products

• 135056-04-1 (5-chloro-2-pirydyl)(2-pirydyl)amine 
• 77064-52-9 2-(N-picrylamino)-5-chloropyridine 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 123488-70-0 2-(5-Chloro-pyridin-2-ylamino)-2-hydroxy-1-phenyl-ethanone 
• 120422-23-3 3-(5-Chloropyrid-2-ylamino)-1-(p-chlorophenyl)-3-phenyl-1-propen-1-one 
• 149221-14-7 methyl 4'-<(4'-chloro-2'-pyridinyl)amino>-6-methyl-2-oxocyclohex-3-en-1-oate 
• 105094-64-2 N-(5-Chlorpyridin-2-ylaminosulfonyl)benzamid 
• 86847-83-8 N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide 
• 79202-10-1 diethylphosphonate 
• 77404-69-4 2-Amino-5-selenocyanatopyridine 
• 128924-82-3 C₁₃H₁₂ClN₃O₃S 
• 118000-62-7 6-Chloro-2-(4-nitro-phenyl)-imidazo[1,2-a]pyridine 
• 130234-74-1 N-(5-Chloro-pyridin-2-yl)-2-hydroxybenzamide 
• 111303-56-1 2-benzyl-8-chloro-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin- 

Relevant articles and documents

Electroorganic synthesis of 6-aminonicotinic acid from 2-amino-5-chloropyridine

A synthesis of 6-aminonicotinic acid by electrochemical hydrogenation of 5-chloro-2-nitropyridine and electrochemical carboxylation of 2-amino-5-chloropyridine at a cathode surface in the presence of sulphuric acid and carbon dioxide in a dimethylformamide (DMF) solution at an apparent current density of 10 mA/cm2 using an undivided cell with good yields is reported.

Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)

N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) has been explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and commercially available N-chloro reagents to reveal the reactivity on a theoretical viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-butyl hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent.

Method for catalytic synthesis of 2-amino-5-chloropyridine by microwave synergistic lewis acidic ionic liquid

The invention relates to a method for catalytic synthesis of 2-amino-5-chloropyridine by microwave synergistic lewis acidic ionic liquid, which comprises the following steps: adding 2-aminopyridine asa raw material into an organic solvent, introducing chlorine under the action of a catalyst lewis acidic ionic liquid and microwave radiation, and carrying out chlorination reaction; and carrying outreduced pressure distillation on the obtained reaction solution to remove the solvent, and further recrystallizing the solution to obtain the high-purity 2-amino-5-chloropyridine. Compared with the prior art, the method has the advantages that the production process is simplified, the reaction conditions are mild, the product purity is higher, the lewis acidic ionic liquid can be recycled, and the production cost is low.

One-step high-efficient high-selective synthesis of 2 - amino -5 - chloro pyridine method (by machine translation)

The invention belongs to the technical field of the synthesis of intermediates, in particular relates to a one-step high-efficient high-selective synthesis of 2 - amino - 5 - chloro pyridine method. In order to 2 - aminopyridine as raw material, in the added to the organic solvent, in the blue LED lamp irradiation, instillment bromide as a catalyst, to be solution after the fading, access chlorine, to carry out a chlorination reaction; the resulting reaction solution is distilled under reduced pressure to obtain crude, further recrystallization to obtain high-purity 2 - amino - 5 - chloro pyridine. This invention adopts the bromine as catalyst, under irradiation of the blue LED lamp, produces the bromine radical with 2 - aminopyridine ring 5 phase combination, then chlorinated, avoid direct chlorinated products caused by 2 - amino - 5 - chloro pyridine series reaction generating multi-chloro, good selectivity of chloride content at the same time higher 2 - amino - 5 - chloro pyridine. The invention compared with the existing technology, the production process is simplified, mild reaction conditions, high product purity, the production cost is low, small amount of waste water. (by machine translation)