138890-88-7

Basic information

• Product Name: 3-Acetyl-2-thiophenesulfonamide
• Synonyms: 3-Acetyl-2-thiophenesulfonamide
• CAS NO: 138890-88-7
• Molecular Formula: C6H7NO3S2
• Molecular Weight: 205.25468
• Mol File: 138890-88-7.mol

Chemical Properties

• Boiling Point: 412.4°C at 760 mmHg
• Flash Point: 203.2°C
• Appearance: /
• Density: 1.472±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 5.19E-07mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 3-Acetyl-2-thiophenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetyl-2-thiophenesulfonamide(138890-88-7)
• EPA Substance Registry System: 3-Acetyl-2-thiophenesulfonamide(138890-88-7)

Safety Data

• Hazardous Substances Data: 138890-88-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H7NO3S2/c1-4(8)5-2-3-11-6(5)12(7,9)10/h2-3H,1H3,(H2,7,9,10)

Upstream product

• 138890-87-6 3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 154127-28-3 3-(2-bromoacetyl)thiophene-2-sulfonamide 
• 138890-97-8 3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide 

Relevant articles and documents

SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE

The present invention relates to new sulfonamide inhibitors of carbonic anhydrase activity, pharmaceutical compositions thereof, and methods of use thereof.

Process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide.

Disclosed herein is an improved process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide (Brinzolamide) and novel intermediates thereof.

IMPROVED PROCESS FOR THE PREPARATION OF (R)-(+)-4-(ETHYIAMINO)-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-2H-THIENO[3,2-E]-L,2-THIAZINE-6-SULFONAMIDE-L,L-DIOXIDE

Disclosed herein is an improved process for the preparation of (R)-(+)-4- (Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6- sulfonamide- 1,1 -dioxide (Brinzolamide) and novel intermediates thereof.

Carbonic anhydrase inhibitors

Compounds of the following formula are disclosed: Compounds of Formula I are the topic of this invention: STR1 Wherein G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from STR2 The compounds are usef

Sulfonamides useful as carbonic anhydrase inhibitors

Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Sulfonamides useful as carbonic anhydrase inhibitors

Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Thiophene sulfonamides useful as carbonic anhydrase inhibitors

Thiophene sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.