2,9-Disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies
A number of N6-(N-arylcarbamoyl)-2-substituted-9-benzyl-8- azaadenines, obtained by a modification of the synthetic scheme used to prepare selective A1 ligands, by only three or two steps, are described. At first we prepared a series
N(6)-substituted 2-N-butyl-9-benzyl-8-azaadenines. Affintiy for adenosine A1 and A2 receptors. IV.
The contribution of a C(2) n-butyl group and an N(6) aliphatic or aromatic group on 9-benzyl-8-azaadenine to affinity towards adenosine A1 and A2 receptors was investigated.