- Cytoprotective activities of kinetin purine isosteres
-
Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replace
- Maková, Barbara,Mik, Václav,Li?ková, Barbora,Gonzalez, Gabriel,Vítek, Dominik,Medvedíková, Martina,Monfort, Beata,Ru?ilová, Veronika,Kadlecová, Alena,Khirsariya, Prashant,Gándara Barreiro, Zoila,Havlí?ek, Libor,Zatloukal, Marek,Soural, Miroslav,Paruch, Kamil,D'Autréaux, Benoit,Hajdúch, Marián,Strnad, Miroslav,Voller, Ji?í
-
-
- Compounds containing a N-heteroaryl moiety linked to fused ring moieties for the inhibition of NAD(P)H oxidases and platelet activation
-
The invention relates to compounds containing a N-heteroaryl moiety, which is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to a fused ring moiety, in particular to the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl radical. The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidases-related diseases and disorders and inhibition of platelet activation.
- -
-
Page/Page column 88
(2008/06/13)
-
- 2,9-Disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies
-
A number of N6-(N-arylcarbamoyl)-2-substituted-9-benzyl-8- azaadenines, obtained by a modification of the synthetic scheme used to prepare selective A1 ligands, by only three or two steps, are described. At first we prepared a series
- Biagi, Giuliana,Bianucci, Anna Maria,Coi, Alessio,Costa, Barbara,Fabbrini, Laura,Giorgi, Irene,Livi, Oreste,Micco, Iolanda,Pacchini, Federica,Santini, Edoardo,Leonardi, Michele,Nofal, Fatena Ahmad,Salerni, Oreste LeRoy,Scartoni, Valerio
-
p. 4679 - 4693
(2007/10/03)
-
- Synthesis and plant growth regulating activity of new triazolo- and pyrazolopyrimidine derivatives of aminomethyl-, aminoalkyloxymethyl dimethylphosphine oxides and (aminomethane)phosphonic acid esters
-
New triazolo[4,5-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives of aminomethyl- and aminomethyloxymethyl dimethylphosphine oxides 8-14 as well as of esters of (aminomethane) phosphonic acid 18-20 were synthesized. The structure of the compounds prepared was confirmed by means of elemental analysis, IR, 1H- and 31P{1H}-NMR spectroscopy. Tertiary phosphine oxides 8, 9 and 12 as well as phosphonate 20 showed herbicidal and plant growth regulating activity.
- Stanoeva, Elena,Varbanov, Sabi,Alexieva, Vera,Sergiev, Iskren,Vasileva, Vesselina,Rashkova, Marieta,Georgieva, Angelina
-
p. 117 - 133
(2007/10/03)
-