139297-39-5

Basic information

• Product Name: N-(2,6-dimethylphenyl)-5-(fluoromethyl)isoxazole-3-carboxamide
• Synonyms: 3-Isoxazolecarboxamide, N-(2,6-dimethylphenyl)-5-(fluoromethyl)-
• CAS NO: 139297-39-5
• Molecular Formula: C₁₃H₁₃FN₂O₂
• Molecular Weight: 248.2529
• Mol File: 139297-39-5.mol

Chemical Properties

• Boiling Point: 325°C at 760 mmHg
• Flash Point: 150.4°C
• Density: 1.249g/cm³
• Vapor Pressure: 0.000237mmHg at 25°C
• Refractive Index: 1.578
• PKA: 11.05±0.70(Predicted)
• CAS DataBase Reference: N-(2,6-dimethylphenyl)-5-(fluoromethyl)isoxazole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-dimethylphenyl)-5-(fluoromethyl)isoxazole-3-carboxamide(139297-39-5)
• EPA Substance Registry System: N-(2,6-dimethylphenyl)-5-(fluoromethyl)isoxazole-3-carboxamide(139297-39-5)

Safety Data

• Hazardous Substances Data: 139297-39-5(Hazardous Substances Data)

Upstream product

• 130403-18-8 D₃₀₁₇ 
• 123770-62-7 ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 
• 215872-15-4 ethyl 5-(fluoromethyl)isoxazole-3-carboxylate 
• 130403-23-5 3-(2,6-dimethyl phenyl carbamoyl)-5-acetoxymethyl isoxazole 
• 139297-57-7 5-acetoxymethyl isoxazole 3-carboxylic acid 
• 139297-56-6 5-(hydroxymethyl)-1,2-oxazole-3-carboxylic acid 
• 145441-16-3 5-fluoromethyl-3-isoxazolecarboxylic acid 
• 87-62-7 2,6-dimethylaniline 

Relevant articles and documents

N(pyrazol-3-yl) benzamides and pharmaceutical compositions

The invention relates to a compound useful for treating epilepsy selected from the compounds of the general formula: STR1 in which R1 is C1 -C4 alkyl, R2 is C1 -C4 alkyl, R3 is selected from hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy and C1 -C4 hydroxyalkyl, and R4 is selected from hydrogen, C1 -C4 alkyl, C2 -C7 alkanoyl and C1 -C4 hydroxyalkyl.

3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions

The object of the invention is heterocyclic compounds of general formula (I) endowed with anticonvulsant activity: STR1 in which Y is selected from --O--, --S-- and STR2 R4 being H or optionally substituted alkyl, acyl or benzyl, Z is selected

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.