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3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 139346-23-9 Structure
  • Basic information

    1. Product Name: 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane
    2. Synonyms: 1-Azabicyclo(2.2.1)heptane, 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-, exo-; 3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane
    3. CAS NO:139346-23-9
    4. Molecular Formula: C11H15N3O
    5. Molecular Weight: 205.2563
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 139346-23-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 344.9°C at 760 mmHg
    3. Flash Point: 162.4°C
    4. Appearance: N/A
    5. Density: 1.3g/cm3
    6. Vapor Pressure: 6.38E-05mmHg at 25°C
    7. Refractive Index: 1.604
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane(139346-23-9)
    12. EPA Substance Registry System: 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane(139346-23-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 139346-23-9(Hazardous Substances Data)

139346-23-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 139346-23-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,3,4 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139346-23:
(8*1)+(7*3)+(6*9)+(5*3)+(4*4)+(3*6)+(2*2)+(1*3)=139
139 % 10 = 9
So 139346-23-9 is a valid CAS Registry Number.

139346-23-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(1-azabicyclo[2.2.1]heptan-3-yl)-3-cyclopropyl-1,2,4-oxadiazole

1.2 Other means of identification

Product number -
Other names L 687,306

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139346-23-9 SDS

139346-23-9Downstream Products

139346-23-9Relevant articles and documents

Enantiospecific Synthesis of the (4R)-1-Azabicycloheptane Ring System

Houghton, Peter G.,Humphrey, Guy R.,Kennedy, Derek J.,Roberts, D. Craig,Wright, Stanley H. B.

, p. 1421 - 1424 (2007/10/02)

An enantioselective synthesis of (4R)-1-azabicycloheptane derivatives is described commencing from readily available trans-4-hydroxy-L-proline which is converted into the key intermediate (3R)-N-(tert-butoxycarbonyl)-3-methylsulfonyloxypyrrolidine 4.Reaction of the sulfonate ester 4 with an enolate anion yields a mixtute of (3R)-pyrrolidineacetic esters 8 and 9 which are reduced to the corresponding alcohols 10 and 11.Conversion of the alcohols into the sulfonate esters 12 and 13 followed by deprotection of the pyrrolidine nitrogen leads to cyclisation yielding the (4R)-1-azabicycloheptane derivatives 14 and 15.

Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma

-

, (2008/06/13)

The use of compounds for formula (I): STR1 or a salt or prodrug thereof; wherein one of X, Y, or Z is an oxygen or sulphur atom and the other two are nitrogen atoms, and the dotted circle represents two double bonds thus forming a 1,3,4-oxadiazole, 1,2,4-oxadiazole, 1,3,4-thiadiazole or 1,2,4-thiadiazole nucleus; R1 represents a non-aromatic azacyclic or azabicyclic ring system selected from STR2 wherein the broken line represents an optional chemical bond; the substituents R3 and R4 may be present at any position, including the point of attachment to the oxa- or thia-diazole ring, and independently represent hydrogen, C1-4 alkyl, halo, C1-4 alkoxy, hydroxy or carboxy, or R3 and R4 together represent carbonyl; the group R5 represents hydrogen or C1-4 alkyl; and R2 represents hydrogen, C1-8 hydrogen, C1-8 alkyl optionally substituted by hydroxy or fluoro, C2-8 alkenyl, OR7, SR7, NR7 R8, CN, CO2 R7, CONR7 R8 OR NHCONHR9 where R9 is C1-4 alkyl; wherein R7 and R8 independently represent hydrogen or saturated or unsaturated C1-4 alkyl provided that, when R7 and R8 in NR7 R8 are both hydrogen, at least one of R3 and R4 is C1-4 alkyl, in the treatment of glaucoma, novel compounds having such use, formulations containing them and their synthesis.

Oxadiazole and its salts, their use in treating dementia

-

, (2008/06/13)

The compound (3R, 4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane and its salts behave as a functionally selective muscarinic agonist and are useful in the treatment of neurological and mental disorders, preferably in a pharmaceutical formulation comprising the active compound in association with a pharmaceutically acceptable carrier. The compound can be prepared by methods analogous to those known in the art via suitable chiral intermediates and cyclopropyl carboxamide oxime.

ENANTIOSELECTIVE SYNTHESIS OF 3-SUBSTITUTED 1-AZABICYCLO(2.2.1)HEPTANES

-

, (2008/06/13)

A process for preparing a substantially pure enantiomer of a compound formula (I) STR1 wherein X is O or S; andR. sup.2 represents hydrogen,--CF 3,--OR 7,--SR 7,--NR 7 R 8,--CN,--COOR 7,--CONR 7 R 8, or a saturated or unsaturated, substituted or unsubstituted hydrocarbon group, wherein R. sup.7 and R. sup.8 are independently selected from hydrogen and C 1-2 alkyl provided that--NR 7 R 8 is other than NH 2 ; which process comprises cyclization of a compound of formula (10) or salt thereof: STR2 wherein X and R 2 are as defined in formula (I); and R 4 is a labile leaving group and optionally epimerizing the endo-diastereomer so prepared to produce the corresponding exo-diastereomer.

Synthesis, Physicochemical and Conformational Properties of (3R,4R)-3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicycloheptane, a Novel M1 Selective Muscarinic Partial Agonist

Baker, Raymond,Showell, Graham A.,Street, Leslie J.,Saunders, John,Hoogsteen, Karst,et al.

, p. 817 - 819 (2007/10/02)

The cyclopropyloxadiazole derivative described in the title has been shown to be a functionally selective M1 partial agonist with antagonist properties in M2 and M3 muscarinic receptor assays; conformational studies indicate free rotation around the oxadiazole-azanorbornane bond, whilst X-ray studies reveal that the cyclopropyl group is in conjugation with the oxadiazole C=N bond.

Lipophilic oxadiazoles

-

, (2014/02/04)

Oxadiazoles of formula I wherein one of X, Y and Z is an oxygen atom and the other two are nitrogen atoms, and the dotted circle represents aromaticity (two double bonds) thus forming a 1,3,4-oxadiazole or 1,2,4-oxadiazole nucleus; R1 represents a non-aromatic azacyclic or azabicyclic ring system; and R2 represents an optionally substituted saturated hyrocarbon group having at least three carbon atoms, or unsaturated hydrocarbon group having at least 6 carbon atoms, have particularly advantageous selective properties for use in the treatment and/or prevention of neurodegenerative diseases.

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