Acid-catalyzed synthesis of α,β-disubstituted conjugated enones by a Meyer-Schuster-type rearrangement in allenols
A novel, direct and simple methodology to gain access to α,β-disubstituted conjugated enones from α-allenols in a sustainable metal catalysis context, considering the inexpensiveness and environmentally friendliness of iron(III) species and protons, has b
Alcaide, Benito,Almendros, Pedro,Cembellín, Sara,Martínez Del Campo, Teresa
p. 1070 - 1078
(2015/03/30)
Synthesis and antimicrobial evaluation of some pyrazole derivatives
Reaction of a series of (E)-3-phenyl-4-(p-substituted phenyl)-3-buten-2- ones with p-sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the ot
Iridium-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones: Enantioselective total synthesis of (-)-mesembrine
A highly efficient asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones catalyzed by chiral spiro iridium complexes for the preparation of chiral 2-substituted allylic alcohols has been developed (ee up to 99.7%). This method provides a concise route to (-)-mesembrine (34% yield, 12 steps).
Regio- and stereochemical aspects of the palladium-catalyzed desilylation-arylation of substituted vinylsilanes
The palladium-catalyzed desilylation-arylation of substituted vinylsilanes by p-iodoanisole in the presence of bidentate phosphine ligands is described. Apart from enhancing the rate of the reaction considerably, heteroatom-based functional groups in the vinylsilane moiety have a profound influence on the regiochemistry. A catalytic cycle for the chelation-controlled desilylation-arylation reaction involving five- and six-membered chelate rings is proposed.
Alvisi, Davide,Blart, Errol,Bonini, Bianca Flavia,Mazzanti, Germana,Ricci, Alfredo,Zani, Paolo
p. 7139 - 7146
(2007/10/03)
Singlet Photochemistry of Vinylcyclopropenes. Regioselectivity and Mechanism: Mechanistic and Exploratory Organic Photochemistry
A study of the direct photochemistry of 1-anisyl-2-phenyl-3-methyl-3-isobutenylcyclopropene (5) was pursued with the objective of elucidating the reaction regioselectivity and casting light on alternative reaction mechanisms for this reaction known to aff
Zimmerman, Howard E.,Wilson, David W.
p. 692 - 697
(2007/10/02)
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