(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymatic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess.
Bernardelli, Patrick,Bladon, Michael,Lorthiois, Edwige,Manage, Ajith C.,Vergne, Fabrice,Wrigglesworth, Roger
p. 1451 - 1455
(2007/10/03)
Reactions of 1-acylamino-1-(trimethylsiloxy)alkanes: Versatile precursors to acylimines
1-Acylamino-1-(trimethylsiloxy)alkanes react with carbon and heteroatom nucleophiles to give the corresponding 1-substituted-1-acylaminoalkanes. The 1-acylamino-1-(trimethylsiloxy)alkanes can also give rise to enamides, and by this route the mild antibiotic tuberin, and the isomeric (Z)-tuberin have been prepared. A further example of their reactions is illustrated with the acid-catalysed intramolecular cyclisation onto a carbon-carbon double bond. These transformations show that 1-acylamino-1-(trimethylsiloxy)alkanes are versatile precursors to synthetically useful acylimines.
Johnson, A. Peter,Luke, Richard W. A.,Boa, Andrew N.
p. 895 - 905
(2007/10/03)
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