Alkylation of 3,5-dichloro-2(1H)-pyrazinones using malonate esters
An efficient base-promoted 3-alkylation of 3,5-dichloro-2(1H)-pyrazinones with various malonate esters is described. The method constitutes a simple example of a C-C bond forming process at the 3-position of the pyrazinone core allowing to attain 3-substituted pyrazinones in good to high yields. 3-Alkylation of 3,5-dichloro-2(1H)-pyrazinones with acetoacetic ester was accompanied by further retro-Claisen fragmentation.
Mishra, Nigam M.,Peshkov, Vsevolod A.,Pereshivko, Olga P.,Modha, Sachin G.,Van Der Eycken, Erik V.
supporting information; experimental part
p. 4676 - 4678
(2012/09/05)
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