- Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand
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Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.
- Liu, Feng,Wu, Na,Cheng, Xu
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supporting information
p. 3015 - 3020
(2021/05/05)
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- Substituted hydrochromenopyrroles
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Compounds of formula (I): STR1 wherein: m is 0 to 3 inclusive, n is 0 to 3 and 2≤m+n≤3, p is 1 to 6 inclusive, X represents cyano or --CO--NR4 R5, R4 and R5 being selected from hydrogen, linear or branched (C1 -C6)-alkyl, (C3 -C7)-cycloalkyl, and aryl, R1 and R2 each independently represent hydrogen or linear or branched (C1 -C6)-alkyl, R3 represents hydrogen, optionally substituted phenyl, naphthyl or heteroaryl, or aryloxy or arylthio, or aryl or heteroaryl substituted by A'-Cy, A' and Cy being as defined in the description, and medicinal products containing the same which are useful as D3 receptor ligands.
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- Thiadiazinone derivatives
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This invention provides thiadiazinone derivatives represented by the following formula (I) STR1 wherein R1 represents a hydrogen atom or C1 -C5 alkyl, R2 represents a 5- or 6-membered heterocyclic ring having (a) 1-3 nitrogen atoms, (b) a oxygen atom, (c) one sulfur atom, (d) 1-3 nitrogen atoms and one oxygen atom, or (e) 1-3 nitrogen atoms and one sulfur atom each of which rings may optionally be substituted by at least one substituent selected from the group consisting of C1 -C5 alkyl, cyano, hydroxy, C1 -C5 alkoxy, amino, C1 -C5 alkylamino, C2 -C6 dialkylamino, C2 -C5 acylamino, carboxyl, C2 -C5 alkoxycarbonyl and carbamoyl; or a pharmaceutically acceptable salt thereof. The compounds according to the present invention have an excellent cardiotonic activity, and are useful as active ingredients of a cardiotonic drug.
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- N-(4-Substituted-thiazolyl)oxamic Acid Derivatives, a New Series of Potent, Orally Actve Antiallergy Agents
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A series of N-(4-substituted-thiazolyl)oxamic acid derivatives were synthesized and tested for antiallergy activity in the rat PCA model.These compounds were conveniently prepared by treatment of the appropriate acetophenone with thiourea and iodine or by reaction of the chloroacetylbenzene with thiourea to give the corresponding aminothiazoles; subsequent condensation with ethyloxalyl chloride gave the thiazolyloxamates.Many of the analogues showed a 50percent inhibition at oxamic acid ethanolamine salt (61, PRH-836-EA), has been selected for further pharmacological evaluation.
- Hargrave, Karl D.,Hess, Friedrich K.,Oliver, James T.
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p. 1158 - 1163
(2007/10/02)
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