140-49-8

Basic information

• Product Name: 4'-(Chloroacetyl)-acetanilide
• Synonyms: 1-acetamido-4-chloroacetylbenzene;1-acetylamino-4-chloroacetylbenzene;4’-(chloroacetyl)-acetanilid;n-(4-(chloroacetyl)phenyl)-acetamid;n-(4-(chloroacetyl)phenyl)acetamide;nci-c03770;p-(acetylamino)phenacylchloride;p-acetamidophenacylchloride
• CAS NO: 140-49-8
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.64
• EINECS: 205-416-8
• Product Categories: ACETYLHALIDE
• Mol File: 140-49-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 216-219 °C(lit.)
• Boiling Point: 303°C (rough estimate)
• Flash Point: 110 °C
• Appearance: Odorless yellow-orange solid or brown powder
• Density: 1.2414 (rough estimate)
• Refractive Index: 1.5500 (estimate)
• PKA: 14.46±0.70(Predicted)
• Water Solubility: <0.1 g/100 mL at 19℃
• CAS DataBase Reference: 4'-(Chloroacetyl)-acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(Chloroacetyl)-acetanilide(140-49-8)
• EPA Substance Registry System: 4'-(Chloroacetyl)-acetanilide(140-49-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: AE1050000
• Hazardous Substances Data: 140-49-8(Hazardous Substances Data)

Usage

Definition

ChEBI: An alpha-chloroketone that is acetanilide in the para- position is substituted by a chloroacetyl group.

General Description

Odorless yellow-orange solid or brown powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4'-(Chloroacetyl)-acetanilide reacts with oxidizers.

Fire Hazard

4'-(Chloroacetyl)-acetanilide is combustible.

Safety Profile

Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also CHLORIDES.

InChI:InChI=1/C10H10ClNO2/c1-7(13)12-9-4-2-8(3-5-9)10(14)6-11/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 79-04-9 chloroacetyl chloride 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 103-84-4 Acetanilid 

Downstream Products

• 100970-13-6 acetic acid-[4-(pyridine-3-sulfonylacetyl)-anilide] 
• 131138-95-9 1-(4-acetylamino-phenyl)-2,3-epoxy-3-phenyl-propan-1-one 
• 25179-47-9 4-(2-p-tolyl-thiazol-4-yl)-aniline 
• 54883-29-3 4-[2-(4-methoxy-phenyl)-thiazol-4-yl]-aniline 
• 25021-49-2 4-(2-methylthiazol-4-yl)benzenamine 
• 25021-48-1 4-(2-phenyl-thiazol-4-yl)-aniline 
• 54883-32-8 4-[2-(4-chloro-phenyl)-thiazol-4-yl]-aniline 
• 75129-22-5 4-[2-(4-nitro-phenyl)-thiazol-4-yl]-aniline 
• 719281-17-1 4-(4'-acetamido-phenyl)-2-(p-methylphenylamino)-thiazole 
• 719281-14-8 4-(4'-acetamido-phenyl)-2-(o-methylphenylamino)-thiazole 
• 877041-97-9 4-(4'-acetamido-phenyl)-2-(o-methoxyphenylamino)-thiazole 
• 160518-39-8 N-{2-Chloro-4-[2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-acetyl]-phenyl}-acetamide; hydrochloride 
• 556-08-1 p-(acetylamino)benzoic acid 
• 99282-59-4 1-(4-aminophenyl)-2-hydroxyethan-1-one 

Relevant articles and documents

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Thiadiazinone derivatives

This invention provides thiadiazinone derivatives represented by the following formula (I) STR1 wherein R1 represents a hydrogen atom or C1 -C5 alkyl, R2 represents a 5- or 6-membered heterocyclic ring having (a) 1-3 nitrogen atoms, (b) a oxygen atom, (c) one sulfur atom, (d) 1-3 nitrogen atoms and one oxygen atom, or (e) 1-3 nitrogen atoms and one sulfur atom each of which rings may optionally be substituted by at least one substituent selected from the group consisting of C1 -C5 alkyl, cyano, hydroxy, C1 -C5 alkoxy, amino, C1 -C5 alkylamino, C2 -C6 dialkylamino, C2 -C5 acylamino, carboxyl, C2 -C5 alkoxycarbonyl and carbamoyl; or a pharmaceutically acceptable salt thereof. The compounds according to the present invention have an excellent cardiotonic activity, and are useful as active ingredients of a cardiotonic drug.