140-49-8

Usage

Uses

Used in Pharmaceutical Industry:
4'-(Chloroacetyl)-acetanilide is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
In the field of organic chemistry, 4'-(Chloroacetyl)-acetanilide serves as a versatile building block for the synthesis of a wide range of chemical products. Its reactivity and functional groups make it a valuable starting material for creating complex molecules with specific properties and applications.
Used in Research and Development:
4'-(Chloroacetyl)-acetanilide is also utilized in research and development laboratories for studying the properties and reactions of alpha-chloroketones. Its unique structure provides insights into the behavior of similar compounds and contributes to the advancement of chemical knowledge.
Used in Analytical Chemistry:
As an analytical reagent, 4'-(Chloroacetyl)-acetanilide can be employed in the detection and quantification of specific substances. Its chemical properties make it suitable for use in various analytical techniques, such as chromatography or spectroscopy, to identify and measure target compounds in complex samples.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4'-(Chloroacetyl)-acetanilide reacts with oxidizers.

Fire Hazard

4'-(Chloroacetyl)-acetanilide is combustible.

Safety Profile

Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also CHLORIDES.

InChI:InChI=1/C10H10ClNO2/c1-7(13)12-9-4-2-8(3-5-9)10(14)6-11/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 79-04-9 chloroacetyl chloride 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 103-84-4 Acetanilid 

Downstream Products

• 100970-13-6 acetic acid-[4-(pyridine-3-sulfonylacetyl)-anilide] 
• 131138-95-9 1-(4-acetylamino-phenyl)-2,3-epoxy-3-phenyl-propan-1-one 
• 65782-58-3 1-(4-acetylamino-phenyl)-2-benzothiazol-2-ylsulfanyl-ethanone 
• 25021-49-2 4-(2-methylthiazol-4-yl)benzenamine 
• 25021-48-1 4-(2-phenyl-thiazol-4-yl)-aniline 
• 54883-32-8 4-[2-(4-chloro-phenyl)-thiazol-4-yl]-aniline 
• 719281-14-8 4-(4'-acetamido-phenyl)-2-(o-methylphenylamino)-thiazole 
• 21674-96-4 N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide 
• 791136-05-5 4-(4'-acetamido-phenyl)-2-(phenylamino)-thiazole 
• 160518-39-8 N-{2-Chloro-4-[2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-acetyl]-phenyl}-acetamide; hydrochloride 
• 861523-03-7 acetic acid-(2,5-dibromo-4-chloroacetyl-anilide) 
• 119457-11-3 N-(4-(2-chloroacetyl)-2-nitrophenyl)acetamide 
• 556-08-1 p-(acetylamino)benzoic acid 
• 130188-51-1 1-(4-amino-phenyl)-2-sulfanilyl-ethanone 

Relevant academic research and scientific papers

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Substituted hydrochromenopyrroles

Compounds of formula (I): STR1 wherein: m is 0 to 3 inclusive, n is 0 to 3 and 2≤m+n≤3, p is 1 to 6 inclusive, X represents cyano or --CO--NR4 R5, R4 and R5 being selected from hydrogen, linear or branched (C1 -C6)-alkyl, (C3 -C7)-cycloalkyl, and aryl, R1 and R2 each independently represent hydrogen or linear or branched (C1 -C6)-alkyl, R3 represents hydrogen, optionally substituted phenyl, naphthyl or heteroaryl, or aryloxy or arylthio, or aryl or heteroaryl substituted by A'-Cy, A' and Cy being as defined in the description, and medicinal products containing the same which are useful as D3 receptor ligands.

Thiadiazinone derivatives

This invention provides thiadiazinone derivatives represented by the following formula (I) STR1 wherein R1 represents a hydrogen atom or C1 -C5 alkyl, R2 represents a 5- or 6-membered heterocyclic ring having (a) 1-3 nitrogen atoms, (b) a oxygen atom, (c) one sulfur atom, (d) 1-3 nitrogen atoms and one oxygen atom, or (e) 1-3 nitrogen atoms and one sulfur atom each of which rings may optionally be substituted by at least one substituent selected from the group consisting of C1 -C5 alkyl, cyano, hydroxy, C1 -C5 alkoxy, amino, C1 -C5 alkylamino, C2 -C6 dialkylamino, C2 -C5 acylamino, carboxyl, C2 -C5 alkoxycarbonyl and carbamoyl; or a pharmaceutically acceptable salt thereof. The compounds according to the present invention have an excellent cardiotonic activity, and are useful as active ingredients of a cardiotonic drug.

N-(4-Substituted-thiazolyl)oxamic Acid Derivatives, a New Series of Potent, Orally Actve Antiallergy Agents

A series of N-(4-substituted-thiazolyl)oxamic acid derivatives were synthesized and tested for antiallergy activity in the rat PCA model.These compounds were conveniently prepared by treatment of the appropriate acetophenone with thiourea and iodine or by reaction of the chloroacetylbenzene with thiourea to give the corresponding aminothiazoles; subsequent condensation with ethyloxalyl chloride gave the thiazolyloxamates.Many of the analogues showed a 50percent inhibition at oxamic acid ethanolamine salt (61, PRH-836-EA), has been selected for further pharmacological evaluation.