- An efficient synthetic method for 1-N,N-dialkylamino-1,3-pentadiynes
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The diyne amines CH3C≡CC≡CNR2 (R = CH3 or C2H5) have been synthesized with greater than 50% overall yields starting from 1,4-dichloro-2-butyne, the last step being a base-catalyzed isomerization of HC≡CC≡CCH2NR2.
- Brandsma,Walda,Oosterveld
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- A quick procedure for the preparation of 1-N,N-dialkylamino-1-buten-3-ynes
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1-N,N-Dialkylamino-1-buten-3-ynes, HC≡CCH=CHNR2 (R = CH3 or C2H5, E/Z ratio ~97:3) have been prepared in 80 and 84% yields by treating the Mannich-coupling products from HC≡CCH2OCH3 and R2NCH2OH, CH3OCH2C≡CCH2NR2, with two equivalents of potassium amide in liquid ammonia and subsequently adding methanol or ammonium chloride.
- Brandsma,Verkruijsse
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- Infrared spectra of dimethylaminomethanol in low-temperature argon matrices and conformational analysis by DFT calculation
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Infrared spectra of dimethylaminomethanol, produced by the visible-light induced reaction between trimethylamine and nitrogen dioxide in low- temperature argon matrices, were recorded by FTIR spectroscopy. The observed bands for the normal, 18O
- Kudoh,Uechi,Takayanagi,Nakata,Tanaka,Shibuya
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- Volatile precursors for deposition of metals and metal-containing films
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This invention is directed to a group of novel homologous eight membered ring compounds having a metal, such as copper, reversibly bound in the ring and containing carbon, nitrogen, silicon and/or other metals. A structural representation of the compounds of this invention is shown below: wherein M and M′ are each a metal such as Cu, Ag, Au and Ir; X and X′ can be N or O; Y and Y′ can be Si, C; Sn, Ge, Al, or B; and Z and Z′ can be C, N, or O. Substituents represented by R1, R2, R3, R4, R5, R6, R1′, R2′, R3′, R4′, R5′, and R6′ will vary depending on the ring atom to which they are attached. This invention is also directed to depositing metal and metal-containing films on a substrate, under ALD or CVD conditions, using the above novel compounds as precursors.
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- Volatile precursors for deposition of metals and metal-containing films
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This invention is directed to a group of novel homologous eight membered ring compounds having a metal, such as copper, reversibly bound in the ring and containing carbon, nitrogen, silicon and/or other metals. A structural representation of the compounds of this invention is shown below: wherein M and M′ are each a metal such as Cu, Ag, Au and Ir; X and X′ can be N or O; Y and Y′ can be Si, C; Sn, Ge, or B; and Z and Z′ can be C, N, or O. Substituents represented by R1, R2, R3, R4, R5, R6, R1′, R2′, R3′, R4′, R5′, and R6′ will vary depending on the ring atom to which they are attached. This invention is also directed to depositing metal and metal-containing films on a substrate, under ALD or CVD conditions, using the above novel compounds as precursors.
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- Aminomethylation of tocopherols
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A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced from a secondary amine, formaldehyde, especially paraformaldehyde, as well as water with one another in about equimolar amounts. The invention is also concerned with a process for the aminomethylation of δ-tocopherol or of tocopherol mixtures containing this and comprises using a Mannich reagent which has been produced in the above manner. After completion of this aminomethylation process excess Mannich reagent can be separated by distillation and can be reacted with water and formaldehyde, especially paraformaldehyde, in order to regenerate further Mannich reagent suitable for use in the aminomethylation, this regeneration representing a further aspect of the invention. Finally, the invention includes certain novel bis(aminomethyl)-γ-tocopherols.
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- The synthesis of primary, secondary and tertiary aminomethyltetrathiafulvalenes
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The title compounds have been prepared in one or two steps, either formyltetrathiafulvalene or tetrathiafulvalenyllithium as starting materials.
- Fabre, Jean-Marc,Garin, Javier,Uriel, Santiago
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p. 3983 - 3990
(2007/10/02)
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- The Production of the Superoxide Radical Anion by the OH Radical-induced Oxidation of Trimethylamine in Oxygenated Aqueous Solution. The Kinetics of the Hydrolysis of (Hydroxymethyl)dimethylamine
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The radiolysis of trimethylamine in N2O/O2 (4:1 v/v) saturated basic solutions eventually gives rise to dimethylamine, formaldehyde, and hydrogen peroxide.Pulse radiolysis using conductivity and optical detection permits the observation of the chemical transformations following the generation of the (dimethylamino)methyl radical from trimethylamine upon attack by the hydoxyl radical.The (dimethylamino)methyl radical reacts rapidly with oxygen (k = 3.5 * 109 M-1 s-1) to give O2(.)(-) and dimethylimonium, possibly via short-lived /t1/2 -6s) peroxyl radical.The dimethylimonium ion adds OH(-) to form (hydroxymethyl)dimethylamine (k = 2.8 * 108 M-1 s-1).This is hydrolyzed to dimethylamine and formaldehyde hydrate (kobs = 4.0 +/- 0.6 s-1).A mechanism incorporating these reactions is shown to be in good accordance with the experimental data in the pH range from 9 to 11.3.
- Das, Suresh,Schuchmann, Man Nien,Schuchmann, Heinz-Peter,Sonntag, Clemens von
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p. 319 - 324
(2007/10/02)
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- Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles
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A novel series of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[β-[4-(β-phenylethyl)phenyl]-β-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.
- Nardi,Tajana,Leonardi,Pennini,Portioli,Magistretti,Subissi
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p. 727 - 731
(2007/10/02)
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