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BMS-906024 is a potent and selective Notch inhibitor that has demonstrated promising antitumor activity in preclinical studies. It targets the Notch signaling pathway, which is crucial for cell survival, proliferation, and differentiation. By inhibiting Notch, BMS-906024 induces cell cycle arrest and apoptosis in various cancer cell lines, including those resistant to chemotherapy.

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  • 1401066-79-2 Structure
  • Basic information

    1. Product Name: BMS-906024
    2. Synonyms: BMS-906024;(2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide
    3. CAS NO:1401066-79-2
    4. Molecular Formula: C26H26F6N4O3
    5. Molecular Weight: 556.5
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1401066-79-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: BMS-906024(CAS DataBase Reference)
    10. NIST Chemistry Reference: BMS-906024(1401066-79-2)
    11. EPA Substance Registry System: BMS-906024(1401066-79-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1401066-79-2(Hazardous Substances Data)

1401066-79-2 Usage

Uses

Used in Oncology:
BMS-906024 is used as an antitumor agent for its ability to suppress tumor growth and metastasis in animal models. It is particularly effective in inducing cell cycle arrest and apoptosis in various cancer cell lines, including those that are resistant to conventional chemotherapy.
Used in Drug Development for Cancer Treatment:
BMS-906024 is used as a potential therapeutic agent in the development of new cancer treatments. Its ability to target the Notch signaling pathway and demonstrate antitumor activity in preclinical studies makes it a promising candidate for further research and development in the field of oncology.

Check Digit Verification of cas no

The CAS Registry Mumber 1401066-79-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,0,6 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1401066-79:
(9*1)+(8*4)+(7*0)+(6*1)+(5*0)+(4*6)+(3*6)+(2*7)+(1*9)=112
112 % 10 = 2
So 1401066-79-2 is a valid CAS Registry Number.

1401066-79-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide

1.2 Other means of identification

Product number -
Other names (2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1401066-79-2 SDS

1401066-79-2Downstream Products

1401066-79-2Relevant articles and documents

A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024

Quesnelle, Claude A.,Gill, Patrice,Kim, Soong-Hoon,Chen, Libing,Zhao, Yufen,Fink, Brian E.,Saulnier, Mark,Frennesson, David,DeMartino, Michael P.,Baran, Phil S.,Gavai, Ashvinikumar V.

, p. 2254 - 2258 (2016/10/19)

An oxidative intermolecular enolate heterocoupling reaction was employed for the synthesis of anti-2,3-disubstituted succinic acid mono- and differentially protected diesters. Tactical approaches to access all the diastereomers are discussed. The method w

Discovery of clinical candidate BMS-906024: A potent pan-notch inhibitor for the treatment of leukemia and solid tumors

Gavai, Ashvinikumar V.,Quesnelle, Claude,Norris, Derek,Han, Wen-Ching,Gill, Patrice,Shan, Weifang,Balog, Aaron,Chen, Ke,Tebben, Andrew,Rampulla, Richard,Wu, Dauh-Rurng,Zhang, Yingru,Mathur, Arvind,White, Ronald,Rose, Anne,Wang, Haiqing,Yang, Zheng,Ranasinghe, Asoka,D'Arienzo, Celia,Guarino, Victor,Xiao, Lan,Su, Ching,Everlof, Gerry,Arora, Vinod,Shen, Ding Ren,Cvijic, Mary Ellen,Menard, Krista,Wen, Mei-Li,Meredith, Jere,Trainor, George,Lombardo, Louis J.,Olson, Richard,Baran, Phil S.,Hunt, John T.,Vite, Gregory D.,Fischer, Bruce S.,Westhouse, Richard A.,Lee, Francis Y.

, p. 523 - 527 (2015/05/27)

Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. On the basis of its robust in vivo efficacy at tolerated doses in

PRODRUGS OF 1,4-BENZODIAZEPINONE COMPOUNDS

-

, (2014/04/04)

Disclosed are compounds of Formula (I) and salts thereof, wherein: a) R1 is H or CH3, and R2 is Ry; or b) R1 is Rx and R2 is H; wherein Rx and Ry are disclosed herein.

BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS

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Page/Page column 28, (2012/10/08)

Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is —CH2CF3 or —CH2CH2CF3; R2 is —CH2CF3, —CH2CH2CF3, or —CH2CH2CH2CF3; R3 is H or —CH3; each Ra is independently F, Cl, —CN, —OCH3, and/or —NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

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