1401066-79-2

Basic information

• Product Name: BMS-906024
• Synonyms: BMS-906024;(2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide
• CAS NO: 1401066-79-2
• Molecular Formula: C₂₆H₂₆F₆N₄O₃
• Molecular Weight: 556.5
• Mol File: 1401066-79-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BMS-906024(CAS DataBase Reference)
• NIST Chemistry Reference: BMS-906024(1401066-79-2)
• EPA Substance Registry System: BMS-906024(1401066-79-2)

Safety Data

• Hazardous Substances Data: 1401066-79-2(Hazardous Substances Data)

Usage

Uses

Used in Oncology:
BMS-906024 is used as an antitumor agent for its ability to suppress tumor growth and metastasis in animal models. It is particularly effective in inducing cell cycle arrest and apoptosis in various cancer cell lines, including those that are resistant to conventional chemotherapy.
Used in Drug Development for Cancer Treatment:
BMS-906024 is used as a potential therapeutic agent in the development of new cancer treatments. Its ability to target the Notch signaling pathway and demonstrate antitumor activity in preclinical studies makes it a promising candidate for further research and development in the field of oncology.

Upstream product

• 1401067-04-6 (2R,3R)-3-(tert-butoxycarbonyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid 
• 1401065-46-0 (4S)-4-benzyl-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one 
• 1401067-07-9 tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate 
• 1186202-35-6 5,5,5-trifluoro-n-valeryl chloride 
• 108895-98-3 benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate 
• 108895-97-2 2-α-(benzyloxycarbonyl)glycinyl)amino>benzophenone 
• 1401067-08-0 (R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid 
• 1401067-00-2 (4S)-4-(propan-2-yl)-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one 
• 1049037-18-4 tert-butyl 5,5,5-trifluoropentanoate 
• 1401067-01-3 tert-butyl (3R)-6,6,6-trifluoro-3-(((4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-2-(3,3,3-trifluoropropyl)hexanoate 
• 107438-84-6 (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, (1S)-(+)-10-camphorsulfonic acid salt 
• 1401067-09-1 (2R,3S)-1-benzyl 4-tert-butyl 2,3-bis(3,3,3-trifluoropropyl)succinate 
• 1401067-34-2 (2S,3R)-6,6,6-trifluoro-3-((⁽³⁵⁾-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoic acid 
• 1401067-05-7 tert-butyl (2S,3R)-6,6,6-trifluoro-3-(((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoate 

Downstream Products

• 1581704-66-6 tert-butyl 2-((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamidothio) ethylcarbamate 
• 1581704-41-7 (2S,3R)-N-((isobutylamino)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-42-8 (2S,3R)-N-((2-Aminoethyl)sulfanyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-43-9 S-(((2S,3R)-6,6,6-trifluoro-3-(((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoyl)amino)-L-cysteine 
• 1581704-45-1 methyl S-(((2S,3R)-6,6,6-trifluoro-3-(((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoyl)amino)-L cysteinate 
• 1581704-44-0 (2S,3R)-N-((2-(Dimethylamino)ethyl)sulfanyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-46-2 (2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-N’((4-methyl-1-piperazinyl)methyl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-47-3 (2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-N’(1-piperidinylmethyl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-69-9 tert-butyl 1-(((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl 2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)methyl)piperidin-4-yl carbamate 
• 1581704-53-1 (2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-N’(1-pyrrolidinylmethyl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-52-0 C₃₃H₄₀F₆N₆O₃ 
• 1581704-51-9 (2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-50-8 (2S,3R)-N-((4-hydroxy-1-piperidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 
• 1581704-49-5 (2S,3R)-N-((4-(dimethylamino)-1-piperidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide 

Relevant articles and documents

A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024

An oxidative intermolecular enolate heterocoupling reaction was employed for the synthesis of anti-2,3-disubstituted succinic acid mono- and differentially protected diesters. Tactical approaches to access all the diastereomers are discussed. The method w

Discovery of clinical candidate BMS-906024: A potent pan-notch inhibitor for the treatment of leukemia and solid tumors

Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. On the basis of its robust in vivo efficacy at tolerated doses in

PRODRUGS OF 1,4-BENZODIAZEPINONE COMPOUNDS

Disclosed are compounds of Formula (I) and salts thereof, wherein: a) R1 is H or CH3, and R2 is Ry; or b) R1 is Rx and R2 is H; wherein Rx and Ry are disclosed herein.

BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS

Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is —CH2CF3 or —CH2CH2CF3; R2 is —CH2CF3, —CH2CH2CF3, or —CH2CH2CH2CF3; R3 is H or —CH3; each Ra is independently F, Cl, —CN, —OCH3, and/or —NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.