Copper (II) chloride: A regioselective catalyst for oxidative aromatization of pyrazoline, isoxazoline and 3-methyl flavanones
A new protocol has been reported in which a series of pyrazoline, isoxazoline and 3-methyl flavanone has been conveniently aromatized by using CuCl2.2H2O in DMSO within a short reaction time in excellent yields. The attraction of this new protocol is regioselective aromatization of substrate 3i-j and 5a-e which has been carried out to afford the aromatized product with O-allyl group intact in excellent yield.
Lokhande, Pradeep D.,Dalvi, Bhakti A.,Humne, Vivek T,Nawghare, Beena R.,Kareem, Abdul
p. 1091 - 1097
(2014/09/30)
Regioselective synthesis of 3,5-diaryl-4-methylisoxazoles
A new class of isoxazole derivatives, namely 2-(3-aryl-4-methylisoxazol-5- yl)phenols, has been efficiently synthesized through the regioselective reaction of 2-aryl-3-methylchromones with hydroxylamine. The products were characterized by spectroscopic me
Lokhande, Pradeep D.,Hasanzadeh, Kamal,Khaledi, Hamid,Ali, Hapipah Mohd
p. 237 - 245
(2013/07/27)
Efficient synthesis of 3-methyl-flavanones and evaluation of their anti-bacterial activity
A series of 2-phenyl-2,3-dihydrochromon-4-one derivatives (flavanone derivatives) were synthesized by silica gel assisted isomerization of several α-methyl-2′-hydroxy chalcones in 74%-88% yield. These flavanones were further oxidized to 3-methyl flavones by using iodine in dimethyl sulphoxide at 60°C in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis.