1403357-11-8

Basic information

• Product Name: 6,8-dichloro-3-methyl-2-phenyl-4H-chromen-4-one
• Synonyms: 6,8-dichloro-3-methyl-2-phenyl-4H-chromen-4-one
• CAS NO: 1403357-11-8
• Molecular Weight: 305.16
• Mol File: 1403357-11-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6,8-dichloro-3-methyl-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-dichloro-3-methyl-2-phenyl-4H-chromen-4-one(1403357-11-8)
• EPA Substance Registry System: 6,8-dichloro-3-methyl-2-phenyl-4H-chromen-4-one(1403357-11-8)

Safety Data

• Hazardous Substances Data: 1403357-11-8(Hazardous Substances Data)

Upstream product

• 90486-52-5 3,5-Dichloro-2-hydroxyphenyl 1-phenylpropen-2-yl ketone 
• 1403356-95-5 C₁₆H₁₂Cl₂O₂ 
• 26628-14-8 2,4-dichlorophenol 
• 18430-74-5 1-(3,5-Dichloro-2-hydroxyphenyl)-1-propanone 

Relevant articles and documents

Copper (II) chloride: A regioselective catalyst for oxidative aromatization of pyrazoline, isoxazoline and 3-methyl flavanones

A new protocol has been reported in which a series of pyrazoline, isoxazoline and 3-methyl flavanone has been conveniently aromatized by using CuCl2.2H2O in DMSO within a short reaction time in excellent yields. The attraction of this new protocol is regioselective aromatization of substrate 3i-j and 5a-e which has been carried out to afford the aromatized product with O-allyl group intact in excellent yield.

Efficient synthesis of 3-methyl-flavanones and evaluation of their anti-bacterial activity

A series of 2-phenyl-2,3-dihydrochromon-4-one derivatives (flavanone derivatives) were synthesized by silica gel assisted isomerization of several α-methyl-2′-hydroxy chalcones in 74%-88% yield. These flavanones were further oxidized to 3-methyl flavones by using iodine in dimethyl sulphoxide at 60°C in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis.