140387-89-9Relevant articles and documents
Use of 1-(8-alpha-ergolinyl)-3,3-diethyl urea derivatives in the treatment of endometritis
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, (2008/06/13)
A composition for the treatment of endometritis in mammalian females which comprises as the physiologically active component a 1-(8alpha-ergolinyl)-3,3-diethylurea of the general formula I in which R1 represents an alkyl group containing from 1 to 3 carbon atoms, R2 represents a hydrogen atom or an alkyl group containing from 1 to 3 carbon atoms and either X stands for a hydrogen atom or both of them form jointly an additional bond between carbon atoms in positions 9 and 10, or a pharmaceutically acceptable acid addition salt thereof. The subject composition of the invention is suitable for treating acute puerperal inflammations and chronic endometritis in mammalian females, especially farm animal females, e.g. cows.
SOLVOLYSIS OF SOME 1-(8α-ERGOLINYL)-3,3-DIETHYLUREAS AND THEIR SALTS
Cerny, Antonin,Benes, Jan,Vachek, Jaroslav,Pesak, Milan,Stuchlik, Josef,et al.
, p. 1331 - 1339 (2007/10/02)
Nine salts of 1-(8α-ergolinyl)-3,3-diethylurea (II) were prepared and their solubility in water and the stability of the aqueous solutions at 60 and 100 deg C were studied.The main product of hydrolysis is 6-methyl-8α-aminoergoline IV.The urethan VII is formed in the ethanolic solution.Both decomposition products are also formed under long-term storage at +5 deg C.The course of hydrolysis of N-propyl homologue III is similar.The decomposition of 9,10-didehydro derivative I is much slower under the conditions used.