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CAS

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1404234-03-2

N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbamic Acid 1,1-Dimethylethyl Ester is a chemical compound that is identified as an impurity in Dapoxetine (D185700), a selective serotonin reuptake inhibitor antidepressant. N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbaMic Acid 1,1-DiMethylethyl Ester is significant in the pharmaceutical industry due to its association with the production and quality control of Dapoxetine.

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  • N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbamic Acid 1,1-Dimethylethyl Ester

    Cas No: 1404234-03-2

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  • 1404234-03-2 Structure

  • Basic information

    1. Product Name: N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbaMic Acid 1,1-DiMethylethyl Ester
    2. Synonyms: N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbaMic Acid 1,1-DiMethylethyl Ester;DYLNOWNCGBJNMC-UHFFFAOYSA-N
    3. CAS NO:1404234-03-2
    4. Molecular Formula: C24H27NO3
    5. Molecular Weight: 377.47608
    6. EINECS: N/A
    7. Product Categories: Amines, Aromatics, Chiral Reagents, Metabolites & Impurities
    8. Mol File: 1404234-03-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator, under inert atmosphere
    8. Solubility: Chloroform, Ethyl Acetate, Methanol
    9. CAS DataBase Reference: N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbaMic Acid 1,1-DiMethylethyl Ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbaMic Acid 1,1-DiMethylethyl Ester(1404234-03-2)
    11. EPA Substance Registry System: N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbaMic Acid 1,1-DiMethylethyl Ester(1404234-03-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1404234-03-2(Hazardous Substances Data)

1404234-03-2 Usage

Uses

Used in Pharmaceutical Industry:
N-[3-(1-Naphthalenyloxy)-1-phenylpropyl]carbamic Acid 1,1-Dimethylethyl Ester is used as an impurity in the production of Dapoxetine (D185700) for its role as a selective serotonin reuptake inhibitor antidepressant. The presence of this compound is crucial for ensuring the quality, safety, and efficacy of the final pharmaceutical product. It is essential to monitor and control the levels of this impurity to maintain the desired therapeutic effects and minimize potential side effects of the antidepressant medication.

Check Digit Verification of cas no

The CAS Registry Mumber 1404234-03-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,4,2,3 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1404234-03:
(9*1)+(8*4)+(7*0)+(6*4)+(5*2)+(4*3)+(3*4)+(2*0)+(1*3)=102
102 % 10 = 2
So 1404234-03-2 is a valid CAS Registry Number.

1404234-03-2Downstream Products

1404234-03-2Relevant articles and documents

Preparation and detection method of dapoxetine hydrochloride isomer impurities

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Paragraph 0013; 0017-0018, (2020/05/01)

The invention discloses a preparation process for preparing a dapoxetine hydrochloride beta-isomer impurity shown as formula I and an enantiomer shown as formula II. The method comprises the following steps: taking optically pure Boc-(S) or (R)-3-amino-3-phenylpropanol as a raw material, performing condensation reaction with 2-fluoronaphthalene or 1-fluoronaphthalene, performing methylation reaction with formic acid-formaldehyde, and performing HCl salification reaction to obtain a target product dapoxetine hydrochloride beta-isomer or enantiomer impurity. Meanwhile, a detection method of isomer impurities is developed.

Preparation method of dapoxetine hydrochloride impurities

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, (2018/06/15)

The invention discloses a preparation method of three impurities with similar structures for dapoxetine hydrochloride: (S)-3-(naphthalene-1-oxo)-1-phenylpropy-1-amine (compound II), (S)-N-methyl-3-(naphthalene-1-oxo)-1-phenylpropy-1-amine (compound III) and (S)-N,N-dimethyl-3-(naphthalene-2-oxo)-1-phenylpropy-1-amine (compound IV). The preparation method comprises the following steps: taking (S)-3-amino-3-phenylpropy-1-ol (VII) as a starting raw material; carrying out a multiple-step reaction such as amino protection, hydroxyl activation, substitution and amino deprotection to respectively obtain a compound II, a compound III and a compound IV as impurities of the dapoxetine hydrochloride. According to a preparation route, the starting raw materials are easy to obtain; reaction conditionsare mild and the selectivity is high; a sample with higher purity (98 percent or above) can be obtained according to a conventional post treatment method, can be used as a reference substance of the compound II, the compound III and the compound IV that are impurities of the dapoxetine hydrochloride and is used for quality control over synthesis research of the dapoxetine hydrochloride.

Midbody for preparing dapoxetine and preparation method for dapoxetine

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Paragraph 0034; 0035, (2018/04/02)

The invention relates to a midbody for preparing dapoxetine and a preparation method for dapoxetine. The dapoxetine hydrochloride with high optical purity can be acquired through a preparation path provided by the invention according to the steps of perfo

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