140681-92-1Relevant articles and documents
Enzymatic synthesis of aza-L-tyrosines
Watkins,Phillips, Robert S.
, p. 2099 - 2100 (2001)
Tyrosine phenol-lyase from Citrobacter freundii synthesizes 2-aza-L-tyrosine and 3-aza-L-tyrosine from 3-hydroxypyridine and 2-hydroxypyridine, respectively, and ammonium pyruvate.
Potential mechanism-based tyrosine kinase inhibitors. Part 2. Design and synthesis of peptides containing heterocyclic tyrosine analogues
Andrews, David M.,Gregoriou, Mary,Page, Timothy C. M.,Peach, Josephine M.,Pratt, Andrew J.
, p. 1335 - 1340 (2007/10/02)
The Fmoc derivatives of two homochiral tyrosine analogues, a pyridine N-oxide and a pyridone, have been prepared in high stereochemical purity.Solid-phase synthesis has been used to prepare a decapeptide substrate for the tyrosine kinase domain of epidermal growth factor.Two decapeptides, which incorporate the tyrosine analogues in place of tyrosine, and thereby have the potential to act as mechanism-based inhibitors of epidermal growth factor tyrosine kinase, have been synthesised and found to inhibit the aforementioned kinase.
New amino acids from the poisonous mushroom Clitocybe acromelalga
Yamano, Kimiaki,Shirahama, Haruhisa
, p. 1457 - 1464 (2007/10/02)
New amino acids, L-3-(2-carboxy-4-pyrrolyl)-alanine (1) and L-3-(2-oxo-5-pyridyl)-alanine (2), were isolated from Clitocybe acromelalga and their structures were deduced by spectral data and biogenesis and confirmed by syntheses. Stizolobic acid (5) was also found in this fungus.
