26218-80-4

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 6-methoxynicotinate is used as an intermediate compound for the synthesis of different types of drugs. Its stability and versatility make it a valuable component in the development of pharmaceutical products.
Safety Precautions:
Methyl 6-methoxynicotinate is used with caution due to its potential irritational effects. It is advised to avoid skin contact or inhalation to prevent any adverse reactions.
Other Names:
Methyl 6-methoxynicotinate is also known as 6-methoxy-nicotinic acid methyl ester, Nicotinic acid, 6-methoxy-, and methyl ester, indicating its various uses in scientific applications.

InChI:InChI=1/C8H9NO3/c1-11-7-4-3-6(5-9-7)8(10)12-2/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 33225-73-9 6-nitronicotinic acid 
• 51834-97-0 6-methoxypyridine-3-ol 

Downstream Products

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 66171-50-4 methyl 6-hydroxynicotinate 
• 58584-63-7 (6-methoxypyridin-3-yl)methanol 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 128632-03-1 5-(bromomethyl)-2-methoxypyridine 
• 65873-72-5 6-methoxy-3-pyridinecarboxaldehyde 
• 140681-94-3 methyl 2-(((benzyloxy)carbonyl)amino)-3-(6-methoxy-3-pyridine-3-yl)acrylate 
• 140701-91-3 Methyl 2-benzyloxycarbonylamino-3-(2-methoxy-5-pyridyl)-propionate 
• 140681-92-1 3-aza-L-tyrosine 
• 31140-71-3 D-3-(2-Oxo-5-pyridyl)-alanine 
• 735264-98-9 2-(4-Methoxyphenyl)-3-(6-methoxy-3-pyridinyl)-3-oxopropanenitrile 
• 909717-77-7 1-amino-5-hydroxymethyl-2-methoxypyridin-1-ium 2,4,6-trimethylbenzenesulfonate 
• 1211515-88-6 2-fluoro-6-methoxypyridine-3-carboxylic acid 
• 117671-03-1 methyl 2-fluoro-6-methoxypyridine-3-carboxylate 

Relevant academic research and scientific papers

ABNORMAL NUCLEOPHILIC SUBSTITUTION OF 3-TRICHLOROMETHYLPYRIDINES BY METHOXIDE

3-Trichloromethylpyridine and its α-chlorinated derivatives behave as ambident electrophilic substrates towards methoxide which attacks an α-position and the trichloromethyl group.

Multiple Paths for Photo-alkylation and -alkoxylation of 3-Pyridinecarboxylic Ester in Alcohol. Simultaneous Contribution of Several Kinds of Excited States

UV-irradiation of methyl 3-pyridinecarboxylate (1) in acidic alcoholic solutions brings about the alkoxylation and alkylation at the pyridine ring.Photoalkylation occurs in several paths: 1) alkylation initiated by the triplet ?-?* state, 2) alkylation initiated by the triplet n-?* state of the carbonyl moiety of the ester group, 3) alkylation initiated by exciplex between a free base form of 1 and a pyridinium form of 1, and 4) alkylation promoted by chloride ions.Photoalkoxylation originates from a singlet excited state of 1.In the photoreactions of 1 in strongly a cidic methanolic solutions acidified with H2SO4, three kinds of excited states (two kinds of triplet states for alkylation and a singlet state for alkoxylation) contribute simultaneously.

Nickel-catalyzed carboxylation of aryl and heteroaryl fluorosulfates using carbon dioxide

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.

Transformations of trichloromethyl groups during reactions of 3-trichloromethylpyridines with methoxide

When methoxide ion attacks an unsubstituted 2- or 6-position of a 3-trichloromethylpyridine, a hydrogen shift leads to a methoxy-substituted 3-dichloromethylpyridine. Further reaction of the dichloromethyl group with methoxide gives the corresponding acetal. This type of reaction has been applied to several chlorinated 3-trichloromethylpyridines and to 3- trichloromethylpyridine itself; a convenient synthesis of the latter is described.

MULTIPLE PATHS FOR PHOTOALKYLATION OF PYRIDINECARBOXYLIC ESTERS IN ALCOHOLS

Photochemical substitution of ring hydrogen of pyridinecarboxylic esters by alkyl groups derived from solvent alcohols occurs in several paths: 1) alkylation initiated by excited carbonyl moiety of the ester group and 2) alkylation initiated by the excitation of the ?-electronic system of the pyridine ring.In the photoreaction of methyl 3-pyridinecarboxylate in acidic methanol, three types of excited state (two triplet states for alkylation and a singlet state for alkoxylation) contribute simultaneously.