- A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines
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Abstract The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl- and 5-cyanothieno[2,3-d]pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was accomplished by building up the functionalized molecule starting from appropriately substituted thiophene precursors. A similar strategy starting from the pyrimidine precursor and subsequent direct functionalization (formylation and cyanation) of the thieno[2,3-d]pyrimidine parent compound in position 5 was found to be less feasible.
- Wilding, Birgit,Faschauner, Stefan,Klempier, Norbert
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p. 4486 - 4489
(2015/06/30)
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- Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives
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A series of thieno[2,3-d]- and thieno[3,2-d]pyrimidines have been easily synthesized using as key step a deproto-cadmiation-trapping sequence. Some of the compounds thus synthesized were screened for anticancer (cytotoxic) activities, and (S)-2-(6-iodo-2-
- Snegaroff, Katia,Lassagne, Frederic,Bentabed-Ababsa, Ghenia,Nassar, Ekhlass,Ely, Sidaty Cheikh Sid,Stephanie Hesse,Perspicace, Enrico,Derdour, Aicha,Mongin, Florence
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experimental part
p. 4782 - 4788
(2009/12/08)
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