14080-52-5Relevant academic research and scientific papers
A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines
Wilding, Birgit,Faschauner, Stefan,Klempier, Norbert
, p. 4486 - 4489 (2015/06/30)
Abstract The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl- and 5-cyanothieno[2,3-d]pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was accomplished by building up the functionalized molecule starting from appropriately substituted thiophene precursors. A similar strategy starting from the pyrimidine precursor and subsequent direct functionalization (formylation and cyanation) of the thieno[2,3-d]pyrimidine parent compound in position 5 was found to be less feasible.
Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives
Snegaroff, Katia,Lassagne, Frederic,Bentabed-Ababsa, Ghenia,Nassar, Ekhlass,Ely, Sidaty Cheikh Sid,Stephanie Hesse,Perspicace, Enrico,Derdour, Aicha,Mongin, Florence
experimental part, p. 4782 - 4788 (2009/12/08)
A series of thieno[2,3-d]- and thieno[3,2-d]pyrimidines have been easily synthesized using as key step a deproto-cadmiation-trapping sequence. Some of the compounds thus synthesized were screened for anticancer (cytotoxic) activities, and (S)-2-(6-iodo-2-
