14080-52-5Relevant articles and documents
A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines
Wilding, Birgit,Faschauner, Stefan,Klempier, Norbert
, p. 4486 - 4489 (2015/06/30)
Abstract The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl- and 5-cyanothieno[2,3-d]pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was accomplished by building up the functionalized molecule starting from appropriately substituted thiophene precursors. A similar strategy starting from the pyrimidine precursor and subsequent direct functionalization (formylation and cyanation) of the thieno[2,3-d]pyrimidine parent compound in position 5 was found to be less feasible.