A CONVENIENT SYNTHESIS OF 3(2)-TRIFLUOROACETYLAMINOBENZOTHIOPHENES AND THIOPHENES AND SOME OF THEIR IODO DERIVATIVES
Trifluoroacetylamino derivatives of benzothiophene and thiophene (3a-d) have been obtained by Curtius rearrangement of the corresponding acyl azides (1a-d) with trifluoroacetic acid.The iodination of these amide derivatives with iodine under mild conditions leads to iodinated products in excellent yield, except in the case of the 3-trifluoroacetylaminobenzothiophene (3a), which only gives a polymeric residue.
Prats, Montserrat,Galvez, Carmen
p. 149 - 156
(2007/10/02)
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