- Clopidogre and wherein the intermediate α-bromo-ortho-chlorophenyl acetic acid and α-thiophene substituted ethylamino- method for the preparation of acetic acid hydrochloride (by machine translation)
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The invention discloses a preparation method of clopidogrel and intermediates thereof. The preparation method of the clopidogrel and intermediates thereof, provided by the invention, has the characteristics of being simple to operate, mild in reaction condition, little in pollution, low in energy consumption and the like and is suitable for industrial production, a high-purity intermediate can be provided for production of the clopidogrel, and the production cost of the clopidogrel is reduced.
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Paragraph 0092
(2017/04/29)
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- Process for racemization
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The invention relates to the racemisation process of the optically active [2-(2-thienyl)ethylamino](2-halogenophenyl)acetamides of general formula (VII) by using basic compounds. The resulting racemic compounds of general formula (VII) can thus be recycle
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Page column 6-7
(2010/02/06)
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