141109-26-4

Basic information

• Product Name: Methyl2-(2-Chlorophenyl)-2-[2-(2-thiophenyl)ethylamino]acetate
• Synonyms: Methyl2-(2-Chlorophenyl)-2-[2-(2-thiophenyl)ethylamino]acetate
• CAS NO: 141109-26-4
• Molecular Formula: C₁₅H₁₆ClNO₂S
• Molecular Weight: 335.84832
• Mol File: 141109-26-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl2-(2-Chlorophenyl)-2-[2-(2-thiophenyl)ethylamino]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2-(2-Chlorophenyl)-2-[2-(2-thiophenyl)ethylamino]acetate(141109-26-4)
• EPA Substance Registry System: Methyl2-(2-Chlorophenyl)-2-[2-(2-thiophenyl)ethylamino]acetate(141109-26-4)

Safety Data

• Hazardous Substances Data: 141109-26-4(Hazardous Substances Data)

Upstream product

• 141109-18-4 methyl [2-(thien-2-yl)ethylamino](2-chlorophenyl)-acetate hydrochloride 
• 89-98-5 2-chloro-benzaldehyde 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 69061-17-2 N-(2-chloro-benzyl)-2-(thien-2-yl)-ethylamine 
• 122853-32-1 C₁₃H₁₂ClNS 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 90055-47-3 methyl 2-chloro-2-(2-chlorophenyl)acetate 
• 34966-49-9 methyl 2-chlorobenzoylformate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 

Downstream Products

• 141109-21-9 (+)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester (-)-camphorsulfonic acid salt 
• 90055-48-4 clopidogrel 

Relevant articles and documents

Synthetic method of racemic clopidogrel

The invention relates to a synthesis method of racemic clopidogrel, which comprises the following steps: 1) uniformly mixing methyl benzoylformate, N-chlorosuccinimide, palladium acetate, a ligand andtrifluoroacetic acid, and carrying out ortho-chlorinati

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Concise Synthesis of (±)-Clopidogrel via Carboxylation of Benzylamine with CO2

A concise and efficient synthesis of (±)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.

A PROCESS FOR PREPARATION OF CLOPIDOGREL

The present invention provides a process for the preparation of S-isomer of methyl α-(4,5,6,7-tetrahydro-5-thieno[3,2-c]pyridyl)(2-chlorophenyl)acetate, a compound of formula (4), or a salt thereof comprising, (a) resolving racemic α-[(2-thien-2-yl)ethylamino]-a-(2-chlorophenyl)methylacetate, a compound of formula 1 or a salt thereof to obtain S-isomer of a compound of formula (1) or a salt thereof and R-isomer of formula (1) or a salt thereof, (b) racemizing the R-isomer of formula 1 or a salt thereof to obtain a racemic compound of formula (1) and optionally converting it into a salt thereof, (c) optionally repeating steps 'a' and 'b', (d) converting the S-isomer of compound of formula (1) obtained in step 'a' to S-isomer of methyl α-(4,5,6,7-tetrahydro-5-thieno[3,2-c]pyridyl)(2-chlorophenyl) acetate.

Process for the preparation of a pharmacologically active substance

The present invention relates to a process for the preparation of the racemic or optically active compounds of general formula (VI): wherein the meaning of X is a halogen atom, or their salts, characterized in that, a racemic or optically active new compound of general formula (VII): wherein the meaning of X is a halogen atom, is transformed into the racemic or optically active compound of general formula (VIII):

Intermediates and process for the preparation thereof

A process for the preparation of [2-(2-thienyl)-ethylamino]-(2-halogenophenyl)-acetonitriles of general formula (I) starting from 2-(2-thienyl)-ethyl-amine, alkalicyanide and o-halogeno-benzaldehyde. Compounds of general formula (I) are valuable intermediates.

Intermediates and process for the preparation thereof

A process for the preparation of 2-[(2-thienyl)-ethylamino]-(2-halogenophenyl)-acetamides of general formula (VII) starting from the nitriles of general formula (I). Compounds of general formula (VII) are valuable intermediates.