141308-25-0Relevant articles and documents
PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues
Abbott, Belinda M.,Thompson, Philip E.
, p. 2847 - 2851 (2004)
Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported
Synthesis and Biological Evaluation of Antiplatelet 2-Aminochromones
Morris, Joel,Wishka, Donn G.,Lin, Alice H.,Humphrey, William R.,Wiltse, Ann L.,et al.
, p. 2026 - 2032 (2007/10/02)
The synthesis and biological evaluation of a series of antiplatelet 2-morpholinylchromones has been described.Modification of the C-7 phenylmethoxy group of 8-methyl-7-(phenylmethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one (2) has led to the discovery of