8-Methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Base Information

Chemical Name:8-Methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
CAS No.:141308-25-0
Molecular Formula:C₂₁H₂₉N₃O₄
Molecular Weight:387.479
Hs Code.:
ChEMBL ID:CHEMBL59941
DSSTox Substance ID:DTXSID00931067
Nikkaji Number:J555.764J
Wikidata:Q82906587
Mol file:141308-25-0.mol

Synonyms:8-methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;MMPEM-benzopyran-4-one

Suppliers and Price of 8-Methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 8-Methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Chemical Property:

Vapor Pressure:1.1E-12mmHg at 25°C
Boiling Point:562.7°C at 760 mmHg
Flash Point:294.1°C
PSA：58.39000
Density:1.215g/cm³
LogP:1.50500
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:387.21580641
Heavy Atom Count:28
Complexity:570

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC2=C1OC(=CC2=O)N3CCOCC3)OCCN4CCN(CC4)C

Technology Process of 8-Methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

There total 13 articles about 8-Methyl-7-(2-(4-methyl-1-piperazinyl)ethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10139-84-1
1-(2,4-dihydroxy-3-methylphenyl)ethanone

: 141308-25-0
8-methyl-7-<2-(4-methyl-1-piperazinyl)ethoxy>-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 1.) Et₂O, RT, overnight, 2.) dichloroethane, 65 deg C, overnight

3: aq. LiOH / methanol / 0.5 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 75 deg C, 30 min, 2.) DMF, 70 deg C, 1 h

With lithium hydroxide; sodium hydride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00066a012

Reference yield:

: 52631-31-9
4-(dichloromethylene)morpholin-4-ium chloride

: 141308-25-0
8-methyl-7-<2-(4-methyl-1-piperazinyl)ethoxy>-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₂O, RT, overnight, 2.) dichloroethane, 65 deg C, overnight

2: aq. LiOH / methanol / 0.5 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 75 deg C, 30 min, 2.) DMF, 70 deg C, 1 h

With lithium hydroxide; sodium hydride; In methanol;
DOI:10.1021/jm00066a012

Reference yield:

: 144224-86-2
4'-(acetyloxy)-2'-hydroxy-3'-methylacetophenone

: 141308-25-0
8-methyl-7-<2-(4-methyl-1-piperazinyl)ethoxy>-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₂O, RT, overnight, 2.) dichloroethane, 65 deg C, overnight

2: aq. LiOH / methanol / 0.5 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 75 deg C, 30 min, 2.) DMF, 70 deg C, 1 h

With lithium hydroxide; sodium hydride; In methanol;
DOI:10.1021/jm00066a012