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141450-48-8

E-7010 monohydrochloride is a chemical compound that functions as a potent and selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). This enzyme is crucial in the regulation of blood flow within the body. By inhibiting PDE5, E-7010 monohydrochloride facilitates the relaxation of smooth muscles in blood vessels, resulting in vasodilation and enhanced blood flow. Its ability to improve blood flow makes it a candidate for therapeutic applications in various medical conditions.

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  • Benzenesulfonamide, N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-, monohydrochloride

    Cas No: 141450-48-8

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  • SAGECHEM LIMITED
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  • N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide monohydrochloride

    Cas No: 141450-48-8

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  • 141450-48-8 Structure

  • Basic information

    1. Product Name: E-7010 monohydrochloride
    2. Synonyms: N-{2-[(4-hydroxyphenyl)aMino]pyridin-3-yl}-4-MethoxybenzenesulfonaMide hydrochloride;BenzenesulfonaMide, N-[2-[(4-hydroxyphenyl)aMino]-3-pyridinyl]-4-Methoxy-, Monohydrochloride;N-[2-[(4-Hydroxyphenyl)aMino]-3-pyridyl]-4-MethoxybenzenesulfonaMide hydrochloride;ABT-751 hydrochloride;ABT-751 monohydrochloride;E-7010 monohydrochloride;N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide monohydrochloride
    3. CAS NO:141450-48-8
    4. Molecular Formula: C18H17N3O4S*ClH
    5. Molecular Weight: 407.87122
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 141450-48-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: pink to purple/
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: DMSO: ≥15mg/mL
    9. CAS DataBase Reference: E-7010 monohydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: E-7010 monohydrochloride(141450-48-8)
    11. EPA Substance Registry System: E-7010 monohydrochloride(141450-48-8)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22-36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 141450-48-8(Hazardous Substances Data)

141450-48-8 Usage

Uses

Used in Erectile Dysfunction Treatment:
E-7010 monohydrochloride is used as a therapeutic agent for erectile dysfunction, where it aids in achieving and maintaining an erection by enhancing blood flow to the penile tissues.
Used in Pulmonary Arterial Hypertension Treatment:
In the treatment of pulmonary arterial hypertension, E-7010 monohydrochloride is utilized to improve blood flow in the pulmonary arteries, reducing the resistance and pressure within these vessels.
Used in Cardiovascular Disease Treatment:
E-7010 monohydrochloride is being explored as a potential treatment for cardiovascular diseases due to its ability to improve blood flow, which can have beneficial effects on the heart and overall cardiovascular health.
Used in Research for Other Blood Flow-Related Conditions:
E-7010 monohydrochloride is used in preclinical studies for its potential application in treating other conditions related to impaired blood flow, as its effects on vasodilation could have wide-ranging therapeutic implications.
E-7010 monohydrochloride is still under clinical trials to assess its safety and efficacy, with the anticipation that it may lead to the development of new treatments for the aforementioned medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 141450-48-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,4,5 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 141450-48:
(8*1)+(7*4)+(6*1)+(5*4)+(4*5)+(3*0)+(2*4)+(1*8)=98
98 % 10 = 8
So 141450-48-8 is a valid CAS Registry Number.

141450-48-8 Well-known Company Product Price

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  • Sigma

  • (SML0131)  ABT-751 hydrochloride  ≥98% (HPLC)

  • 141450-48-8

  • SML0131-5MG

  • 1,168.83CNY

  • Detail

  • Sigma

  • (SML0131)  ABT-751 hydrochloride  ≥98% (HPLC)

  • 141450-48-8

  • SML0131-25MG

  • 4,722.12CNY

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141450-48-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide,hydrochloride

1.2 Other means of identification

Product number -
Other names N-[2-[(4-Hydroxyphenyl)amino]-3-pyridyl]-4-methoxybenzenesulfonamide hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141450-48-8 SDS

141450-48-8Downstream Products

141450-48-8Relevant articles and documents

Crystalline N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide hydrochloride

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Page/Page column 3, (2008/06/13)

Crystalline N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide hydrochloride, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.

Amorphous N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide hydrochloride

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Page/Page column 2, (2008/06/13)

Amorphous N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide hydrochloride, processes for making it, compositions containing it and methods of treatment of diseases using it are disclosed.

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