Welcome to LookChem.com Sign In|Join Free

CAS

  • or

98-68-0

Post Buying Request

98-68-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

98-68-0 Usage

Uses

4-Methoxybenzenesulfonyl chloride is used as an anti-HIV as Pharmaceutical Intermediates. It also acts as protecting group agent for various nitrogen functions.

Synthesis Reference(s)

Synthesis, p. 852, 1986 DOI: 10.1055/s-1986-31803

Check Digit Verification of cas no

The CAS Registry Mumber 98-68-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 98-68:
(4*9)+(3*8)+(2*6)+(1*8)=80
80 % 10 = 0
So 98-68-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H7ClO3S/c1-11-6-2-4-7(5-3-6)12(8,9)10/h2-5H,1H3

98-68-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (M0802)  4-Methoxybenzenesulfonyl Chloride  >98.0%(GC)(T)

  • 98-68-0

  • 25g

  • 490.00CNY

  • Detail
  • TCI America

  • (M0802)  4-Methoxybenzenesulfonyl Chloride  >98.0%(GC)(T)

  • 98-68-0

  • 100g

  • 1,350.00CNY

  • Detail
  • TCI America

  • (M0802)  4-Methoxybenzenesulfonyl Chloride  >98.0%(GC)(T)

  • 98-68-0

  • 500g

  • 4,650.00CNY

  • Detail
  • Alfa Aesar

  • (A13788)  4-Methoxybenzenesulfonyl chloride, 98+%   

  • 98-68-0

  • 25g

  • 514.0CNY

  • Detail
  • Alfa Aesar

  • (A13788)  4-Methoxybenzenesulfonyl chloride, 98+%   

  • 98-68-0

  • 100g

  • 1376.0CNY

  • Detail
  • Alfa Aesar

  • (A13788)  4-Methoxybenzenesulfonyl chloride, 98+%   

  • 98-68-0

  • 500g

  • 5530.0CNY

  • Detail
  • Aldrich

  • (M10204)  4-Methoxybenzenesulfonylchloride  99%

  • 98-68-0

  • M10204-5G

  • 321.75CNY

  • Detail
  • Aldrich

  • (M10204)  4-Methoxybenzenesulfonylchloride  99%

  • 98-68-0

  • M10204-25G

  • 625.95CNY

  • Detail

98-68-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Methoxybenzenesulfonyl Chloride

1.2 Other means of identification

Product number -
Other names 4-METHOXYBENEZENESULFONYLCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98-68-0 SDS

98-68-0Synthetic route

4-Methoxybenzenethiol
696-63-9

4-Methoxybenzenethiol

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;99%
With trichloroisocyanuric acid; water In acetonitrile at 0 - 20℃; for 0.333333h;99%
With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃; for 0.0166667h;98%
methylthiocarbamic acid S-(4-methoxyphenyl)ester

methylthiocarbamic acid S-(4-methoxyphenyl)ester

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃;98.1%
S-(4-methoxyphenyl) ethanethioate
60787-31-7

S-(4-methoxyphenyl) ethanethioate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃;97.7%
4,4'-dimethoxyphenyl disulfide
5335-87-5

4,4'-dimethoxyphenyl disulfide

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h;96%
With dihydrogen peroxide; trichlorophosphate In water at 25℃; for 0.5h; Micellar solution;95%
With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid In dichloromethane; water at 0 - 20℃; Inert atmosphere;92%
4-methoxybenzenesulfonic acid
5857-42-1

4-methoxybenzenesulfonic acid

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; potassium chloride at 25℃; for 0.0333333h; Neat (no solvent);94%
methoxybenzene
100-66-3

methoxybenzene

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With sulfuryl dichloride; sulfuric acid In N,N-dimethyl-formamide88%
With chlorosulfonic acid at 0 - 5℃;71.32%
With chlorosulfonic acid at 0 - 5℃;71.42%
1-benzylsulfanyl-4-methoxy-benzene
26905-24-8

1-benzylsulfanyl-4-methoxy-benzene

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid In dichloromethane; water at 0 - 5℃; Inert atmosphere;86%
S-4-methoxyphenyl benzothioate
24197-73-7

S-4-methoxyphenyl benzothioate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With trichloroisocyanuric acid; benzyltrimethylammonium chloride; sodium carbonate In water; acetonitrile at 0℃; for 0.333333h;81%
4-methoxybenzenediazonium tetrafluoroborate
459-64-3

4-methoxybenzenediazonium tetrafluoroborate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With thionyl chloride; tris(bipyridine)ruthenium(II) dichloride hexahydrate In water; acetonitrile at 20℃; for 20h; Concentration; Sealed tube; Irradiation;71%
4-Methoxybenzenethiol
696-63-9

4-Methoxybenzenethiol

chloroamine-T
127-65-1

chloroamine-T

A

N-chloro-N-(4-methylbenzenesulfonyl)-4-methoxybenzenesulfinamide

N-chloro-N-(4-methylbenzenesulfonyl)-4-methoxybenzenesulfinamide

B

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With N-chloro-succinimide In water; acetonitrile at 35℃; for 0.25h;A 70%
B 27%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
Stage #1: 4-methoxy-aniline With tris(bipyridine)ruthenium(II) dichloride hexahydrate; isopentyl nitrite In acetonitrile at 20℃; for 0.0833333h; Sealed tube;
Stage #2: With thionyl chloride In water; acetonitrile at 20℃; for 20h; Irradiation;
63%
Stage #1: 4-methoxy-aniline With hydrogenchloride; acetic acid
Stage #2: With sodium nitrite In water at -10 - -5℃; for 0.75h;
Stage #3: With hydrogenchloride; sulfur dioxide; acetic acid; copper(l) chloride In water at 10℃; for 0.5h;
27%
With tert.-butylnitrite; sulfur dioxide; N-benzyl-N,N,N-triethylammonium chloride; ethylene glycol; copper dichloride In dichloromethane; acetonitrile at 0 - 20℃; Automated synthesizer;
Stage #1: 4-methoxy-aniline With tetrafluoroboric acid; tert.-butylnitrite In ethanol; water at 0 - 20℃; for 1h;
Stage #2: With 6,6'-dimethyl-2,2'-bipyridine; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; potassium chloride; copper dichloride In acetonitrile at 20℃; for 12h; Sealed tube; Inert atmosphere;
50 mg
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

methoxybenzene
100-66-3

methoxybenzene

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
In dichloromethane for 2h;60%
(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

para-methoxyphenyldiazonium chloride
4346-59-2

para-methoxyphenyldiazonium chloride

A

4-(4-methoxyphenylsulfonyl)-1-phenyl-2-nitroethane
56129-62-5

4-(4-methoxyphenylsulfonyl)-1-phenyl-2-nitroethane

B

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With sulfur dioxide In acetic acid; acetoneA 30%
B n/a
nitrostyrene
5153-67-3

nitrostyrene

para-methoxyphenyldiazonium chloride
4346-59-2

para-methoxyphenyldiazonium chloride

A

4-(4-methoxyphenylsulfonyl)-1-phenyl-2-nitroethane
56129-62-5

4-(4-methoxyphenylsulfonyl)-1-phenyl-2-nitroethane

B

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With sulfur dioxide In acetic acid; acetone at 15 - 20℃;A 30%
B n/a
phenylchlorosulfate
16475-29-9

phenylchlorosulfate

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

A

4-methoxybenzolsulfonsaeure-phenylester
62141-81-5

4-methoxybenzolsulfonsaeure-phenylester

B

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With t-BuBrettPhos; palladium diacetate; potassium carbonate In toluene at 75℃; for 12h; Reagent/catalyst; Suzuki-Miyaura Coupling;A 15%
B 22%
para-methoxyphenyldiazonium chloride
4346-59-2

para-methoxyphenyldiazonium chloride

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With sulfur dioxide; copper(l) chloride
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
Yield given. Multistep reaction;
Stage #1: 1-bromo-4-methoxy-benzene With iodine; magnesium In tetrahydrofuran for 1h; Heating;
Stage #2: With sulfur dioxide In tetrahydrofuran at -40℃; for 0.5h;
Stage #3: With sulfuryl dichloride In tetrahydrofuran at -40 - 20℃;
(p-methoxyphenyl)tri-n-butylstannane
70744-47-7

(p-methoxyphenyl)tri-n-butylstannane

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With sulfuryl dichloride at 20℃; for 4h;
Trifluoro-acetic acid 4-methoxy-phenylsulfanylmethyl ester

Trifluoro-acetic acid 4-methoxy-phenylsulfanylmethyl ester

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With chlorine; acetic acid In dichloromethane Yield given;
potassium salt of/the/ p-anisolesulfonic acid

potassium salt of/the/ p-anisolesulfonic acid

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride at 100℃;
sodium-<4-methoxy-benzene sulfonate-(1)>

sodium-<4-methoxy-benzene sulfonate-(1)>

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride
para-iodoanisole
696-62-8

para-iodoanisole

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; 1,10-Phenanthroline; N-ethyl-N,N-diisopropylamine / toluene / 16 h / Reflux
2: trichloroisocyanuric acid; benzyltrimethylammonium chloride; sodium carbonate / water; acetonitrile / 0.33 h / 0 °C
View Scheme
4-methylphenyl chlorosulfate
772-80-5

4-methylphenyl chlorosulfate

2,6-diisopropylphenyl chlorosulfate
1447963-66-7

2,6-diisopropylphenyl chlorosulfate

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

A

p-cresol
106-44-5

p-cresol

B

2,6-diisopropylphenol
2078-54-8

2,6-diisopropylphenol

C

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
Stage #1: 4-methoxyphenylboronic acid With C43H43NO3PPdS; sodium carbonate In [(2)H6]acetone at 20℃; Inert atmosphere; Sealed tube;
Stage #2: 4-methylphenyl chlorosulfate; 2,6-diisopropylphenyl chlorosulfate In [(2)H6]acetone at 50℃; for 10h;
A 43 %Spectr.
B 72 %Spectr.
C 97 %Spectr.
4-methylphenyl chlorosulfate
772-80-5

4-methylphenyl chlorosulfate

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

A

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

B

p-tolylboric acid
274251-50-2

p-tolylboric acid

Conditions
ConditionsYield
With C43H43NO3PPdS; sodium carbonate In [(2)H6]acetone at 60℃; for 6h;
4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With phenylchlorosulfate; C43H43NO3PPdS; sodium carbonate In acetone at 50℃; for 12h; Inert atmosphere;
phenol
108-95-2

phenol

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / methanol / 5 h / 0 - 60 °C / Inert atmosphere
2: dichloromethane / 2 h
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / methanol / 5 h / 0 - 20 °C / Inert atmosphere
2: chlorosulfonic acid / dichloromethane / -5 °C
View Scheme
sodium 4-methoxy-benzenesulfonate
6140-09-6

sodium 4-methoxy-benzenesulfonate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide for 4h; Reflux;
sodium p-hydroxybenzenesulfonate
825-90-1

sodium p-hydroxybenzenesulfonate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / methanol / Reflux
2: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux
View Scheme
4-methoxybenzene sulfonamide
1129-26-6

4-methoxybenzene sulfonamide

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Conditions
ConditionsYield
With pyrylium tetrafluoroborate; magnesium chloride In tert-butyl alcohol at 60℃; for 3h;
4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

4-methoxybenzenesulfonyl azide
4547-64-2

4-methoxybenzenesulfonyl azide

Conditions
ConditionsYield
With sodium azide In water; acetone at 0 - 20℃; for 11h; Sealed tube;100%
With sodium azide In water; acetone97%
With sodium azide; tributyl methyl phsophonium chloride immobibized on polystyrene matrix In 1,2-dichloro-ethane at 45℃; for 4h;96%
4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

4-methoxybenzenesulfonyl hydrazide
1950-68-1

4-methoxybenzenesulfonyl hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In tetrahydrofuran at 0℃;100%
With hydrazine hydrate In tetrahydrofuran at 5℃; for 0.5h;95%
With hydrazine hydrate In tetrahydrofuran at 5℃; for 0.5h; Cooling with ice;95%
Tr-Trp-OBzl
83595-58-8

Tr-Trp-OBzl

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

Tr-Trp(Mbs)-OBzl
83595-60-2

Tr-Trp(Mbs)-OBzl

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide Ambient temperature; 1.) 2 h, 2.) 15 h;100%
2-Aminobenzyl alcohol
5344-90-1

2-Aminobenzyl alcohol

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

N-(2-hydroxymethylphenyl)-4-methoxybenzenesulfonamide
601481-95-2

N-(2-hydroxymethylphenyl)-4-methoxybenzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;100%
With pyridine In dichloromethane at 20℃;
With pyridine In dichloromethane Reflux;
With pyridine In dichloromethane at 0 - 20℃; for 2h;
With pyridine In dichloromethane at 20℃; for 4h;
3,4,5-triacetoxy-6-[4-(3-amino-pyridin-2-ylamino)-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester
930121-05-4

3,4,5-triacetoxy-6-[4-(3-amino-pyridin-2-ylamino)-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

3,4,5-triacetoxy-6-{4-[3-(4-methoxy-benzenesulfonylamino)-pyridin-2-ylamino]-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester
930121-03-2

3,4,5-triacetoxy-6-{4-[3-(4-methoxy-benzenesulfonylamino)-pyridin-2-ylamino]-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With pyridine100%
4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

1-amino-2-propene
107-11-9

1-amino-2-propene

N-allyl-4-methoxybenzenesulfonamide
34954-40-0

N-allyl-4-methoxybenzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 19h; Inert atmosphere;100%
With triethylamine In dichloromethane at 0 - 20℃;96%
With sodium hydroxide In diethyl ether; water at 20℃; for 5h; Schotten-Baumann reaction;73%
4-(4-aminomethylbenzyl)-nitrobenzene

4-(4-aminomethylbenzyl)-nitrobenzene

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

4-[4-(4-methoxyphenyl)sulfonylaminomethylbenzyl]-nitrobenzene

4-[4-(4-methoxyphenyl)sulfonylaminomethylbenzyl]-nitrobenzene

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate
1161026-84-1

tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

tert-butyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
1053613-59-4

tert-butyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water for 12h;100%
piperidin-4-one
41661-47-6

piperidin-4-one

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

1-(4-methoxybenzenesulfonyl)-4-piperidone
196085-08-2

1-(4-methoxybenzenesulfonyl)-4-piperidone

Conditions
ConditionsYield
With pyridine at 20℃; for 18h;100%
C21H35NO12

C21H35NO12

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

methyl 2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl-(1->4)-6-deoxy-6-(4-methoxyphenylsulfonylamino)-2,3-di-O-methyl-α-D-galactopyranoside
1356387-27-3

methyl 2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl-(1->4)-6-deoxy-6-(4-methoxyphenylsulfonylamino)-2,3-di-O-methyl-α-D-galactopyranoside

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
2-(1,1-dimethylethyl)-benzenamine
6310-21-0

2-(1,1-dimethylethyl)-benzenamine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

N-(2-(tert-butyl)phenyl)-4-methoxybenzenesulfonamide

N-(2-(tert-butyl)phenyl)-4-methoxybenzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;100%
4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

sodium 4-methoxybenzenesulfinate
6462-50-6

sodium 4-methoxybenzenesulfinate

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium sulfite In tetrahydrofuran; water at 0 - 20℃;99.9%
With sodium hydrogencarbonate; sodium sulfite In water at 80℃; for 4h;92%
With sodium hydrogencarbonate; sodium sulfite In water at 80℃; for 4h;92%
m-Anisidine
536-90-3

m-Anisidine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

4-methoxy-N-(3-methoxyphenyl)benzenesulfonamide
169945-40-8

4-methoxy-N-(3-methoxyphenyl)benzenesulfonamide

Conditions
ConditionsYield
Stage #1: m-Anisidine With pyridine In dichloromethane for 0.166667h;
Stage #2: 4-methoxy-phenyl-sulphonyl chloride In dichloromethane for 0.25h;
99.6%
2.50 g (99.7%)
In dichloromethane at 20℃; for 3h; Inert atmosphere;
piperazine
110-85-0

piperazine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

1‐(4‐methoxyphenylsulfonyl)piperazine
121751-67-5

1‐(4‐methoxyphenylsulfonyl)piperazine

Conditions
ConditionsYield
In dichloromethane at 0℃;99%
In dichloromethane at 0 - 20℃;96%
Stage #1: piperazine; 4-methoxy-phenyl-sulphonyl chloride With pyridine In dichloromethane at 20℃; for 15h;
Stage #2: With hydrogenchloride In water
88%
2-phenylethynylaniline
13141-38-3

2-phenylethynylaniline

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

4-methoxy-N-(2-(phenylethynyl)phenyl)benzenesulfonamide
946161-94-0

4-methoxy-N-(2-(phenylethynyl)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 19.5h;99%
With pyridine In dichloromethane at 0 - 20℃;
With pyridine In chloroform at 20℃;
With pyridine In dichloromethane at 0 - 25℃; for 72h; Inert atmosphere; Schlenk technique;0.96 g
3-methyl-1-[3-(4-methylbenzyl)-[1,2,4]thiadiazol-5-yl]piperazine
854539-15-4

3-methyl-1-[3-(4-methylbenzyl)-[1,2,4]thiadiazol-5-yl]piperazine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

1-[4-methoxyphenylsulfonyl]-4-[3-(4-methylbenzyl)-1,2,4-thiadiazol-5-yl]-2-methylpiperazine

1-[4-methoxyphenylsulfonyl]-4-[3-(4-methylbenzyl)-1,2,4-thiadiazol-5-yl]-2-methylpiperazine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 4h;99%
With triethylamine In dichloromethane at 20℃; for 4h;99%
3-acetylindole
703-80-0

3-acetylindole

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

3-acetyl-1-((4-methoxyphenyl)sulfonyl)indole

3-acetyl-1-((4-methoxyphenyl)sulfonyl)indole

Conditions
ConditionsYield
Stage #1: 3-acetylindole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 4-methoxy-phenyl-sulphonyl chloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Cooling with ice;
99%
With potassium carbonate In acetone at 20℃; for 12h; Inert atmosphere;
1-(1H-indol-3-yl)hexan-1-one
42925-75-7

1-(1H-indol-3-yl)hexan-1-one

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

C21H23NO4S
1352537-20-2

C21H23NO4S

Conditions
ConditionsYield
Stage #1: 1-(1H-indol-3-yl)hexan-1-one With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 4-methoxy-phenyl-sulphonyl chloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Cooling with ice;
99%
1-(1H-indol-3-yl)pentan-1-one
42925-74-6

1-(1H-indol-3-yl)pentan-1-one

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

C20H21NO4S
1352537-18-8

C20H21NO4S

Conditions
ConditionsYield
Stage #1: 1-(1H-indol-3-yl)pentan-1-one With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 4-methoxy-phenyl-sulphonyl chloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Cooling with ice;
99%
7-benzyloxy-5-bromoindoline

7-benzyloxy-5-bromoindoline

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

7-benzyloxy-5-bromo-1-(4-methoxyphenylsulfonyl)indoline

7-benzyloxy-5-bromo-1-(4-methoxyphenylsulfonyl)indoline

Conditions
ConditionsYield
With pyridine at 95℃; Inert atmosphere;99%
C12H19N3O4

C12H19N3O4

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

C19H25N3O7S

C19H25N3O7S

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 16h;99%
4-tert-Butylaniline
769-92-6

4-tert-Butylaniline

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

N-(4-(tert-butyl)phenyl)-4-methoxybenzenesulfonamide

N-(4-(tert-butyl)phenyl)-4-methoxybenzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;99%
2-bromobenzylamine
3959-05-5

2-bromobenzylamine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

N-(2-bromobenzyl)-4-methoxybenzenesulfonamide

N-(2-bromobenzyl)-4-methoxybenzenesulfonamide

Conditions
ConditionsYield
With pyridine at 90℃; Inert atmosphere;99%
D-Ser(O-t-Bu) methyl ester hydrochloride
78537-14-1

D-Ser(O-t-Bu) methyl ester hydrochloride

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

C15H23NO6S

C15H23NO6S

Conditions
ConditionsYield
Stage #1: D-Ser(O-t-Bu) methyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;
Stage #2: 4-methoxy-phenyl-sulphonyl chloride In dichloromethane at 0 - 20℃; for 4h;
99%
Stage #1: D-Ser(O-t-Bu) methyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;
Stage #2: 4-methoxy-phenyl-sulphonyl chloride With dmap In dichloromethane at 0 - 20℃; for 4h;
99%
glycine tert-butyl ester hydrochloride
27532-96-3

glycine tert-butyl ester hydrochloride

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

tert-butyl ((4-methoxyphenyl)sulfonyl)glycinate

tert-butyl ((4-methoxyphenyl)sulfonyl)glycinate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;99%
With pyridine at 20℃; for 4h;54%
6-((4S,5S)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-2,2′-bipyridine

6-((4S,5S)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-2,2′-bipyridine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

6-((4S,5S)-1-((4-methoxyphenyl)sulfonyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-2,2′-bipyridine

6-((4S,5S)-1-((4-methoxyphenyl)sulfonyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-2,2′-bipyridine

Conditions
ConditionsYield
With dmap In dichloromethane at 0℃; for 4h; Schlenk technique;99%
4-((4-methoxyphenyl)ethynyl)naphthalen-1-amine

4-((4-methoxyphenyl)ethynyl)naphthalen-1-amine

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

4-methoxy-N-(4-((4-methoxyphenyl)ethynyl)naphthalen-1-yl)benzenesulfonamide

4-methoxy-N-(4-((4-methoxyphenyl)ethynyl)naphthalen-1-yl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine Sealed tube;99%
With pyridine at 20℃; for 18h;99%
(R)-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)pyrrolidine-2-carboxamide hydrochloride

(R)-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)pyrrolidine-2-carboxamide hydrochloride

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

(R)-N-(5,6-dimethoxybenzo[d] thiazol-2-yl)-1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxamide

(R)-N-(5,6-dimethoxybenzo[d] thiazol-2-yl)-1-((4-methoxyphenyl)sulfonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With pyridine In acetonitrile for 14h;99%
methyl (R,E)-4-(3-amino-1-benzyl-5-bromo-2-oxoindolin-3-yl)but-2-enoate

methyl (R,E)-4-(3-amino-1-benzyl-5-bromo-2-oxoindolin-3-yl)but-2-enoate

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

methyl (R,E)-4-[1-benzyl-5-bromo-3-(4-methoxybenzenesulfonamide)-2-oxoindolin-3-yl]but-2-enoate

methyl (R,E)-4-[1-benzyl-5-bromo-3-(4-methoxybenzenesulfonamide)-2-oxoindolin-3-yl]but-2-enoate

Conditions
ConditionsYield
With pyridine In chloroform at 0 - 20℃; for 26h; Inert atmosphere;99%

98-68-0Relevant articles and documents

N-ARYL SULFONAMIDE DERIVATIVES AS VACCINE ADJUVANT

-

Page/Page column 101-102, (2021/02/26)

Bis-aryl sulfonamide compounds and methods of using those compounds, e.g., in a method of enhancing or prolonging an immune response, are provided. For example, the compounds may be employed with a vaccine and optionally at least one other adjuvant and/or one or more TLR ligands, at least one MAP kinase inhibitor, or any combination thereof.

Sulfonimidesversusketosulfonamides as epoxidized imidazolium counterions: Towards a new generation of ionic liquid monomers

Chardin,Durand,Jarsalé,Rouden,Livi,Baudoux

supporting information, p. 2953 - 2957 (2021/02/26)

The design of novel ionic liquid monomers with attractive properties represents a real challenge in the field of poly(ionic liquid)s (PILs). Here, we describe a comparative study of the synthesis of original PIL precursors from various sulfonimides or ketosulfonamides as unprecedented counteranions of imidazolium ILs. These salts were submitted to the Prilezhaev reaction and a first insight into the intrinsic properties of these new epoxy monomers was unveiled, in particular the thermal stability of these advanced epoxy salts by comparison with traditional counterions.

Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao

, (2021/09/20)

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 98-68-0