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BOC-VAL-NCA, also known as N-tert-butoxycarbonyl-N-α-carbobenzyloxy-L-valine N-carboxyanhydride, is a chemical compound used in organic synthesis and peptide chemistry. It is a derivative of valine and is a reagent for the preparation of N-protected valine derivatives which can be used in the production of various functional materials and pharmaceuticals. BOC-VAL-NCA is often used in the solid-phase peptide synthesis as a coupling reagent to introduce valine into peptide chains. BOC-VAL-NCA is also known for its ability to form stable and reactive derivatives under mild conditions, making it a valuable tool in peptide chemistry research and manufacturing.

141468-55-5

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141468-55-5 Usage

Uses

Used in Pharmaceutical Industry:
BOC-VAL-NCA is used as a reagent for the preparation of N-protected valine derivatives for the production of various functional materials and pharmaceuticals.
Used in Peptide Chemistry Research and Manufacturing:
BOC-VAL-NCA is used as a coupling reagent in solid-phase peptide synthesis to introduce valine into peptide chains, due to its ability to form stable and reactive derivatives under mild conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 141468-55-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,4,6 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 141468-55:
(8*1)+(7*4)+(6*1)+(5*4)+(4*6)+(3*8)+(2*5)+(1*5)=125
125 % 10 = 5
So 141468-55-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H17NO5/c1-6(2)7-8(13)16-9(14)12(7)10(15)17-11(3,4)5/h6-7H,1-5H3/t7-/m0/s1

141468-55-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Boc-L-Valine N-carboxyanhydride

1.2 Other means of identification

Product number -
Other names Boc-Valine,NCA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141468-55-5 SDS

141468-55-5Relevant articles and documents

Method of obtaining urethane-protected n-carboxyanhydrides of alpha amino acids

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Page/Page column 3-4, (2008/06/13)

The invention relates to a method of preparing urethane-protected N-carboxyanhydrides of alpha amino acids. The inventive method enables the synthesis of urethane-protected N-carboxyanhydrides of alpha amino acids in the presence of a catalytic quantity of triethylene diamine without the addition of a tertiary amine-type base.

N-Alkoxycarbonyl Amino Acid N-Carboxyanhydrides and N,N-Dialkoxycarbonyl Amino Acid Fluorides from N,N-Diprotected Amino Acids

Savrda, J.,Wakselman, M.

, p. 812 - 813 (2007/10/02)

Activation of N,N-bis-Boc or N-Boc N-Z amino acids with SOCl2-DMF leads to N-protected N-carboxy amino acid anhydrides, whereas treatment with cyanuric fluoride at low temperature gives mainly N,N-bis-protected amino acid fluorides, which are efficient ac

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