182007-77-8Relevant academic research and scientific papers
Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase
Silvers, Molly A.,Robertson, Gregory T.,Taylor, Carol M.,Waldrop, Grover L.
, p. 8947 - 8959 (2015/03/14)
There is an urgent demand for the development of new antibiotics due to the increase in drug-resistant pathogenic bacteria. A novel target is the multifunctional enzyme acetyl-CoA carboxylase (ACC), which catalyzes the first committed step in fatty acid s
Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action
Pohlmann, Jens,Lampe, Thomas,Shimada, Mitsuyuki,Nell, Peter G.,Pernerstorfer, Josef,Svenstrup, Niels,Brunner, Nina A.,Schiffer, Guido,Freiberg, Christoph
, p. 1189 - 1192 (2007/10/03)
The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure-activity relationship (SAR) studies revealed a high degree of variability for the fa
Asymmetric syntheses of moiramide B and andrimid
Davies, Stephen G.,Dixon, Darren J.
, p. 2635 - 2643 (2007/10/03)
The first highly diastereoselective asymmetric syntheses of moiramide B 2 and andrimid 3 have been achieved using lithium amide (R)-6 and pyrrolidinone auxiliary (R)-9. Pyrrolidinone auxiliary (R)-9 was used to create the novel (S)-3-methyl-N-benzyloxysuc
Asymmetric synthesis of moiramide B
Dixon, Darren J.,Davies, Stephen G.
, p. 1797 - 1798 (2007/10/03)
The first asymmetric synthesis of Moiramide B 1 is achieved using lithium amide 4 and pyrrolidinone auxiliary 5; pyrrolidinone auxiliary 5 is used to create the novel (S)-2-methyl-N-benzyloxysuccinimide 15 which is subsequently acylated with the highly re
