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Hydrazinoacetic acid, also known as 2-hydrazinoacetic acid, is an organic compound with the chemical formula NH2NHCOCH2COOH. It is a derivative of acetic acid, featuring a hydrazine functional group attached to the carbonyl carbon. hydrazinoacetic acid has potential applications in the pharmaceutical and medical fields due to its unique chemical structure and properties.

14150-64-2

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14150-64-2 Usage

Uses

Used in Pharmaceutical Industry:
Hydrazinoacetic acid is used as an IL-17 and IFN-γ inhibitor for treating autoimmune diseases and chronic inflammation. By inhibiting these inflammatory cytokines, hydrazinoacetic acid can help modulate the immune response and alleviate symptoms associated with various autoimmune conditions and chronic inflammatory disorders. This makes it a promising candidate for the development of novel therapeutics in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 14150-64-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,5 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14150-64:
(7*1)+(6*4)+(5*1)+(4*5)+(3*0)+(2*6)+(1*4)=72
72 % 10 = 2
So 14150-64-2 is a valid CAS Registry Number.
InChI:InChI=1/C2H6N2O2/c3-4-1-2(5)6/h4H,1,3H2,(H,5,6)

14150-64-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-hydrazinylacetic acid

1.2 Other means of identification

Product number -
Other names Hydrazinomethancarbonsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14150-64-2 SDS

14150-64-2Relevant articles and documents

N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides

Manoj Kumar, Mesram,Venkataramana, Parikibanda,Yadagiri Swamy, Parikibanda,Chityala, Yadaiah

supporting information, p. 17713 - 17721 (2021/11/10)

A new route to synthesis of various mono-N-substituted hydrazines and hydrazides by involving in a new C?N bond formation by using N-amino-1,8-naphthalimide as a regenerated precursor was invented. Aniline and phenylhydrazines are reproduced upon reacting these individually with 1,8-naphthalic anhydride followed by hydrazinolysis. The practicality and simplicity of this C?N dihalo alkanes; developed a synthon for bond formation protocol was exemplified to various hydrazines and hydrazides. N-amino-1,8-naphthalimide is suitable synthon for transformation for selective formation of mono-substituted hydrazine and hydrazide derivatives. Those are selective mono-amidation of hydrazine with acid halides; mono-N-substituted hydrazones from aldehydes; synthesis of N-aminoazacycloalkanes from acetohydrazide scaffold and inserted to hydroxy derivatives; distinct synthesis of N,N-dibenzylhydrazines and N-benzylhydrazines from benzyl halides; synthesis of N-amino-amino acids from α-halo esters. Ecofriendly reagent N-amino-1,8-naphthalimide was regenerated with good yields by the hydrazinolysis in all procedures.

Synthesis method of ethyl hydrazinoacetate hydrochloride

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Paragraph 0015; 0018; 0021; 0024; 0027; 0030, (2019/01/23)

The invention discloses a synthesis method of ethyl hydrazinoacetate hydrochloride and belongs to the technical field of organic synthesis. The technical scheme is characterized in that chloroacetic acid is used as an initial material to react with hydrazine hydrate to produce intermediate hydrazine acetic acid, hydrazine acetic acid and ethanol form ester to obtain ethyl hydrazinoacetate, a hydrogen chloride solution is added to react to obtain a crude product of ethyl hydrazinoacetate hydrochloride, and high-purity ethyl hydrazinoacetate hydrochloride is obtained through refinement. The method has the advantages of being mild in reaction condition, high in yield, high in purity, low in cost, economical, environmentally friendly, applicable to industrialization and the like and is a synthesis method with industrial production values.

STRAIGHT-CHAIN AND BRANCHED-CHAIN LIPID COMPOUNDS AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2, ANTI-INFLAMMATORY AGENTS, AND ANTI-CANCER AGENTS

-

Page/Page column 14-15, (2008/06/13)

Unique branched-chain lipid compounds are disclosed as selective COX-2 inhibitors, which are derivatives of a branched-chain fatty amine or a branched-chain fatty amide, or a pharmaceutically acceptable salt thereof. The compounds can be used for osteoarthritis and rheumatoid arthritis as anti-inflammatory agents, in addition to treating and preventing cancer. Straight-chain analogs of the branched-chain lipid compounds provide similar uses.

Solution phase synthesis of imidazo[1,2-b]pyrazol-2-one, an interesting 5,5-fused heterocyclic ring system

Blass, Benjamin E.,Srivastava, Anil,Coburn, Keith R.,Faulkner, Amy L.,Janusz, John J.,Ridgeway, James M.,Seibel, William L.

, p. 619 - 621 (2007/10/03)

The solution phase synthesis of a series of imidazo[1,2-b]pyrazol-2-ones, a fused 5,5-ring system, based on diverse set of hydrazino acids and malononitriles is described. The method involves formation of 5-aminopyrazoles followed by intra-molecular cyclodehydration.

Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid

Vaillancourt,Larsen,Tanis,Burr,Connell,Cudahy,Evans,Fisher,May,Meglasson,Robinson,Stevens,Tucker,Vidmar,Yu

, p. 1231 - 1248 (2007/10/03)

3-Guanidinopropionic acid (1) has been demonstrated both to improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). However, 1 has also been shown to be a substrate for both the creatine transporter and creatine kinase, leading to marked accumulation in muscle tissue as the corresponding N-phosphate. The corresponding aminoguanidine analogue 2 was recently discovered to retain the antidiabetic activity of 1 while being markedly less susceptible to creatine-like metabolism, suggesting that it should have less potential to accumulate in muscle. Further structural modification of 2 was undertaken to investigate whether the antidiabetic potency could be augmented while maintaining resistance to creatine-like metabolism. Modifications such as α-alkylation, homologation, and bioisosteric replacement of the aminoguanidine all were detrimental to antidiabetic activity. However, the simple regioisomeric aminoguanidinoacetic acid 9 and diaminoguanidinoacetic acid analogue 7 were found to be equipotent to 2, leading eventually to the discovery of the significantly more potent diaminoguanidinoacetic acid regioisomers 52 and 53. Further attempts to modify the more active template represented by 52 led only to reductions in antidiabetic activity. Each of the new active analogues displayed the same resistance to creatine-like metabolism as 2. Further testing of 7, 9, and 53 in obese diabetic ob / ob mice confirmed that weight loss is induced selectively from adipose tissue, similar to the lead 1. Administration of 53 to insulin-resistant rhesus monkeys led to reductions in both fasting and post-prandial plasma glucose levels with concomitant reductions in plasma insulin levels, suggesting that the compound improved the action of endogenous insulin. Compounds 7 and 53 were selected for further preclinical development.

Gut-selective opiates

-

, (2008/06/13)

Gut-selective agonist or antagonist opiates of the formula: STR1 wherein R is (C1 -C5)alkyl, C3 -C6 (cycloalkyl)alkyl, aryl, aralkyl or trans-(C2 -C5)alkenyl; Z is H or OH, R' is (C=O)-A(B)(C) wherein A is selected from the group consisting of (C1 -C5)alkyl, (C2 -C5)alkenyl and (C2 -C6)alkoxy (alkyl); B is selected from the group consisting of H, amino and a (C1 -C5)alkyl group optionally substituted with CO2 H, OH or phenyl and C is CO2 H, SO3 H, amino or guanidino; and R" is selected from the group consisting of NH-A(B)(C) or is guanidino; and the pharmaceutically-acceptable salts thereof.

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