Synthesis of 2-phosphonoheterocycles via base-promoted 5-endo cyclization
Herein, a synthesis of 2-phosphonodihydrofurans and 2-phosphonodihydropyrroles via 5-endo cyclization of O-and N-propargylated compounds is described. The reaction is promoted by potassium tert-butoxide and allows a fast access to interesting heterocycles which were easily converted into 2-arylated pyrroles under acidic conditions.
Highly efficient and extremely simple protocol for the oxidation α-hydroxyphosphonates to α-ketophosphonates using Dess-Martin periodinane
Dess-Martin periodinane has been demonstrated for the first time to be an efficient reagent in metal - free oxidation of α-hydroxyphosphonates to α-ketophosphonates under ambient conditions. Acquiescent reaction conditions and a simple isolation procedure
Palladium-catalyzed asymmetric hydrogenation of N-hydroxya-imino phosphonates using bronsted acid as activator: The first catalytic enantioselective approach to chiral N-hydroxy-aamino phosphonates
The enantioselective synthesis of ring-substituted [N-(hydroxy)amino] ACHTUNGTRENUNG(phenyl)methylphos- ACHTUNGTRENUNGphonic esters via asymmetric hydrogenation of the corresponding N-hydroxy-a-imino phosphonates with up to 90% ee was developed using cata
Asymmetric hydrogenation of α-keto phosphonates with chiral palladium catalysts
Under atmospheric hydrogen pressure, a catalytic amount of palladium(II) trifluoroacetate and (R)-MeO-BIPHEP in 2,2,2-trifluoroethanol promoted the asymmetric hydrogenation of diisopropyl α-keto phosphonates 1 to afford the corresponding α-hydroxy phospho
Goulioukina, Nataliya S.,Bondarenko, Grigorii N.,Bogdanov, Alexei V.,Gavrilov, Konstantin N.,Beletskaya, Irina P.
experimental part
p. 510 - 515
(2009/07/19)
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