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141804-42-4

KNI 174 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 141804-42-4 Structure

  • Basic information

    1. Product Name: KNI 174
    2. Synonyms: KNI 174
    3. CAS NO:141804-42-4
    4. Molecular Formula: C35H43N5O7S
    5. Molecular Weight: 677.819
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 141804-42-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 1075°C at 760 mmHg
    3. Flash Point: 603.9°C
    4. Appearance: /
    5. Density: 1.269g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.608
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: KNI 174(CAS DataBase Reference)
    11. NIST Chemistry Reference: KNI 174(141804-42-4)
    12. EPA Substance Registry System: KNI 174(141804-42-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 141804-42-4(Hazardous Substances Data)

141804-42-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 141804-42-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,0 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141804-42:
(8*1)+(7*4)+(6*1)+(5*8)+(4*0)+(3*4)+(2*4)+(1*2)=104
104 % 10 = 4
So 141804-42-4 is a valid CAS Registry Number.
InChI:InChI=1/C36H45N5O7S/c1-35(2,3)40-33(46)31-36(4,5)49-21-41(31)34(47)30(44)25(18-22-12-7-6-8-13-22)39-32(45)26(19-28(37)42)38-29(43)20-48-27-17-11-15-23-14-9-10-16-24(23)27/h6-17,25-26,30-31,44H,18-21H2,1-5H3,(H2,37,42)(H,38,43)(H,39,45)(H,40,46)/t25-,26-,30?,31+/m0/s1

141804-42-4Downstream Products

141804-42-4Relevant articles and documents

Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere

Mimoto, Tsutomu,Hattori, Naoko,Takaku, Haruo,Kisanuki, Sumitsugu,Fukazawa, Tominaga,Terashima, Keisuke,Kato, Ryohei,Nojima, Satoshi,Misawa, Satoru,Ueno, Takamasa,Imai, Junya,Enomoto, Hiroshi,Tanaka, Shigeki,Sakikawa, Hiroshi,Shintani, Makoto,Hayashi, Hideya,Kiso, Yoshiaki

, p. 1310 - 1326 (2007/10/03)

We designed and synthesized a new class of peptidomimetic human immunodeficiency virus protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid], with a hydroxymethylcarbonyl isostere as the active moiety. From a structure-activity relationship study of HIV-1 protease inhibition, enzyme selectivity for other aspartyl proteases, the antiviral activity and pharmacokinetics in rats, 24c (KNI-227) and 24d (KNI-272, our first clinical candidate) were found to be selective and orally potent HIV protease inhibitors. Moreover, an improvement of the pharmacokinetic features of KNI-272 provided two long-lasting and highly bioavailable compounds (24g: JE-2178,h: JE-2179).

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