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3-Amino-1H-benzo[f]chromene-2-carbonitrile is a chemical compound with the molecular formula C14H10N2. It is a derivative of benzo[f]chromene, a tricyclic aromatic compound, and features an amino group at the 3-position and a nitrile group at the 2-position. 3-Amino-1H-benzo[f]chromene-2-carbonitrile is known for its potential applications in the synthesis of various pharmaceuticals and organic compounds due to its unique structure and reactivity. It is an important intermediate in the preparation of certain drugs and can be used in the development of novel chemical entities with potential therapeutic properties.

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  • 141987-72-6 Structure
  • Basic information

    1. Product Name: 3-Amino-1H-benzo[f]chromene-2-carbonitrile
    2. Synonyms: 3-Amino-1H-benzo[f]chromene-2-carbonitrile
    3. CAS NO:141987-72-6
    4. Molecular Formula: C14H10N2O
    5. Molecular Weight: 222.242
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 141987-72-6.mol
  • Chemical Properties

    1. Melting Point: 196 °C
    2. Boiling Point: 495.5±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.32±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 3.08±0.20(Predicted)
    10. CAS DataBase Reference: 3-Amino-1H-benzo[f]chromene-2-carbonitrile(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-Amino-1H-benzo[f]chromene-2-carbonitrile(141987-72-6)
    12. EPA Substance Registry System: 3-Amino-1H-benzo[f]chromene-2-carbonitrile(141987-72-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 141987-72-6(Hazardous Substances Data)

141987-72-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 141987-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,9,8 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141987-72:
(8*1)+(7*4)+(6*1)+(5*9)+(4*8)+(3*7)+(2*7)+(1*2)=156
156 % 10 = 6
So 141987-72-6 is a valid CAS Registry Number.

141987-72-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-amino-1H-benzo[f]chromene-2-carbonitrile

1.2 Other means of identification

Product number -
Other names 3-amino-1H-naphtho<2,1-b>pyran-2-carbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141987-72-6 SDS

141987-72-6Downstream Products

141987-72-6Relevant articles and documents

An eco-friendly synthesis of 2-aminochromenes and indolyl chromenes catalyzed by InCl3 in aqueous media

Shanthi, Gnanamani,Perumal, Paramasivan T.

, p. 6785 - 6789 (2007)

A simple and convenient method for the synthesis of new 2-aminochromenes and indolyl chromenes via an indium trichloride catalyzed, three-component reaction in aqueous media is described.

Microwave-assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities

Bouattour, Ali,Fakhfakh, Mehdi,Abid, Souhir,Paquin, Ludovic,Le Guével, Rémy,Corlu, Anne,Ruchaud, Sandrine,Bach, Stéphane,Ammar, Houcine,Bazureau, Jean-Pierre

, p. 291 - 302 (2017/06/19)

The synthesis of a series of new 4-imino-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thiones 6(a-f) without substituent in C-5 position using microwave dielectric heating is reported. These new compounds were obtained in three steps with good overall y

Synthesis, antifungal activity and docking study of 2-amino-4H-benzochromene-3-carbonitrile derivatives

Mirjalili, BiBi Fatemeh,Zamani, Leila,Zomorodian, Kamiar,Khabnadideh, Soghra,Haghighijoo, Zahra,Malakotikhah, Zahra,Ayatollahi Mousavi, Seyyed Amin,Khojasteh, Shaghayegh

, p. 102 - 108 (2017/01/12)

Pathogenic fungi are associated with diseases ranging from simple dermatosis to life-threatening infections, particularly in immunocompromised patients. During the past two decades, resistance to established antifungal drugs has increased dramatically and

Convenient synthesis of 2-Amino-4H-chromenes from photochemically generated o-quinone methides and malononitrile

Fujiwara, Makoto,Sakamoto, Masanori,Komeyama, Kimihiro,Yoshida, Hiroto,Takaki, Ken

, p. 59 - 66 (2015/01/30)

2-Amino-4H-chromenes were synthesized in moderate to good yields by the reaction of o-quinone methides photochemically generated from o-(dimethylaminomethyl)phenols with malononitrile. This method was applicable to the synthesis of fluorinated chromenes that were difficult to obtain by other methods. In addition, o-(hydroxymethyl)phenols could be used for the reaction in the presence of tertiary amine bases.

Recyclable Bi2WO6-nanoparticle mediated one-pot multicomponent reactions in aqueous medium at room temperature

Paplal, Banoth,Nagaraju,Veerabhadraiah, Palakollu,Sujatha, Kodam,Kanvah, Sriram,Vijaya Kumar,Kashinath, Dhurke

, p. 54168 - 54174 (2015/02/18)

Different types of multicomponent reactions (MCRs) are reported using Bi2O3, BiVO4, and Bi2WO6 (nanoparticle) as heterogeneous catalysts. Among these, Bi2WO6 nanoparticles showed excellent reactivity for the synthesis of functionalized dihydropyridine, polyhydroquinoline, 4H-chromene and 2-amino-4H-benzo[b]pyran derivatives at ambient temperature in aqueous medium. All the reactions gave good to excellent yields in 10-45 minutes in the presence of 5 mol% (optimized) of the catalyst. The catalyst was regenerated and reused up to 5 times without losing catalytic activity. The gram scale synthesis of dihydropyridine gave the desired product in 82% yield in 2 h. This journal is

New synthesis of 3-amino-1H-benzo[f]chromene-2-carbonitriles

Osipov,Osyanin,Klimochkin, Yu. N.

, p. 398 - 402 (2013/07/26)

3-Amino-1H-benzo[f]chromene-2-carbonitriles were synthesized by non-catalytic reaction from Mannich bases of the naphthalene series and malononitrile. Reactive 1-benzylidene(or methylidene)naphthalen-2(1H)-ones were presumed as intermediate products.

Convenient one-step synthesis of 4-unsubstituted 2-amino-4H-chromene-2- carbonitriles and 5-unsubstituted 5H-chromeno[2,3-b]pyridine-3-carbonitriles from quaternary ammonium salts

Osyanin, Vitaly A.,Osipov, Dmitry V.,Klimochkin, Yuri N.

experimental part, p. 5612 - 5618 (2012/09/21)

We have reported DBU catalyzed synthesis of 4-unsubstituted 2-amino-4H-chromene-2-carbonitriles in water under reflux. The attractive features of this process are mild reaction conditions, short reaction times, easy isolation of products and good yields.

Nitriles in Heterocyclic Synthesis. The Reaction of Polyhydric Naphthalenes, 4-Methylcoumarin-3-carbonitrile, and Alkylidenemalononitrile with Methylenemalononitrile

Elagamey, Abdel Ghani Ali,El-Taweel, Fathy Mohamed Abdel-Aziz,Khodeir, Mohamed Nabil Mohamed,Elnagdi, Mohamed Hilmy

, p. 464 - 468 (2007/10/02)

2-Naphthol and naphthalenediols react with methylenemalononitrile, generated in situ from reaction of formaldehyde and malononitrile, to yield naphthopyrans and naphthodipyrans. 5-Hydroxynaphthopyrans reacted further with methylenemalononitrile to yield naphthodipyrans.The reaction of methylenemalononitrile with 4-methylcoumarin-3-carbonitrile afforded benzopyranoquinoline. 6-Cyanomethyl-3-pyridinecarbonitriles, prepared via reacting 1-arylethylidenemalononitriles with malononitrile, afforded 4H-quinolizines on treatment with methylenemalononitrile.

Studies with Polyfunctionally Substituted Heterocycles: Synthesis of New Pyridines, Naphthopyrans, Pyrazolo(3,4-b>pyridines and Pyrazolopyrimidines

Elnagdi, Mohamed Hilmy,Elghandour, Ahmed Hafiz Husein,Ibrahim, Mohamed Kamal Ahmed,Hafiz, Ibrahim Saad Abdel

, p. 572 - 578 (2007/10/02)

A variety of new polyfunctionally substituted pyridines, naphthopyrans and pyrazolopyrimidines were prepared via reacting ylidenemalononitriles with thiophenol, thionaphthol, naphthols or aminopyrazoles. Keywords: Heterocycles, Pyridines, Pyrimidines

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