80860-05-5

Upstream product

• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 109-77-3 malononitrile 
• 86108-12-5 N-(2-hydroxy-1-naphthyl)methylene-4-acetylaniline 
• 889954-31-8 2-(2-bromoethoxy)-1-naphthaldehyde 

Downstream Products

• 141987-72-6 3-amino-1H-naphtho<2,1-b>pyran-2-carbonitrile 

Relevant academic research and scientific papers

A facile naphthalene-based fluorescent chemodosimeter for mercury ions in aqueous solution

A facile naphthalene-based fluorescence turn-on chemodosimeter, 2-((2-(vinyloxy)naphthalen-1-yl)methylene)-malononitrile (MS1), for rapid, selective and sensitive detection of Hg2+ by mercury-promoted hydrolysis of the vinylether group has been reported. The probe displayed a fast response time, and a sensitive fluorescence response (100-fold fluorescence enhancement) to the detection of Hg2+ in aqueous solution. This journal is

Synthesis of 2-amino-4-(2-hydroxynaphthyl)-4H-chromene-3-carbonitriles by Michael addition and their transformaion into new pentacyclic compounds

2-Amino-4-(2-hydroxynaphthyl)-4H-chromene-3-carbonitriles were synthesized by Michael addition of various 3-cyanoiminocoumarins and β-naphthol in good yield. The heterocyclization of these materials in an acidic medium leads new heterocyclic compounds, which have not previously been described, in moderate to good yields and good selectivity. The synthesized compounds were characterized by infrared, 1H NMR, 13C NMR, two-dimensional NMR, and elemental analysis.

Synthesis of new benzopyrano[2,3-c]pyrazoles and 3- triazolonyliminocoumarins from 3-cyano iminocoumarin derivatives

Synthesis of benzopyrano[2,3-c]pyrazoles and 3-triazolonyliminocoumarins was successfully performed using heterocyclization of 3-cyano iminocoumarin or their N-ethoxycarbonylated derivatives with semicarbazide reagents. Elemental analysis, infrared, and

Simple, efficient procedure for the synthesis of benzopyrano[2,3-c] isoxazoles

Synthesis of 3-imino-benzopyrano[2,3-c]isoxazoles was successfully performed using heterorocyclization of 2-imino-2H-1-benzopyrano 3-carbonitrile derivatives with hydroxylamine. The synthesized compounds were characterized by infrared, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis. Copyright Taylor & Francis Group, LLC.

Synthesis of 4H-chromene-isoxazole hybrids via ortho-hydroxy directing cyclization of isoxazole-styrenes and Michael addition of imino-chromenes in aqueous medium

A green, efficient, and one-pot method synthesis of functionalized 4H-chromene-isoxazole hybrids is reported via o-hydroxy group directing cyclization of isoxazole-styrenes and Michael addition of 3,5-dimethyl-4-nitroisoxazole on 2-imino-2H-chromene-3-carbonitrile (independent methods). The developed methodology was further extended for nitromethane, malononitrile, and alkylcyanoacetates as Michael donors.

Enantioselective vinylogous Michael addition of β,γ-unsaturated butenolide to 2-iminochromenes

An efficient organocatalyzed asymmetric synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles via vinylogous Michael addition of non-activated β,γ-unsaturated butenolide to 2-iminochromenes has been realized.

Reaction of cyano active methylene compounds with 2-hydroxy-1-naphthal-4-acetylaniline: An unexpected result

Condensation of cyano active methylene compounds (1-5) with 2-hydroxy-1-naphthal-4-acetylaniline, the compound containing both carbon-nitrogen double bond as well as carbon-oxygen double bond, in equimolar ratio resulted in the formation of crude solids (

DBU-catalyzed synthesis of novel 2-Amino-3-nitrile-4H-chromenes

A simple method via the base-catalyzed Michael addition of nitroalkanes to 2-iminochromenes was developed, which leads to the production of highly functionalized 2-Amino-3-nitrile-4H-chromenes in good yields.

Microwave-assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities

The synthesis of a series of new 4-imino-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thiones 6(a-f) without substituent in C-5 position using microwave dielectric heating is reported. These new compounds were obtained in three steps with good overall y

A facile naphthalene-based fluorescent 'turn-on' chemodosimeter for palladium ions in aqueous solution

A novel and simple depropargylation-triggered spontaneous cyclization reaction based fluorescent turn-on chemodosimeter for the detection of Pd2+ has been reasonably designed and developed. Based on the specific reactivity of palladium ion-promoted hydrolysis reaction, the probe exhibited a high selectivity and sensitivity for Pd2+ with a low detection limit (53 nM, 5.7 μg/L) under physiological conditions in neutral PBS (only containing 1% organic cosolvent) without any additional reagents.