142078-36-2

Basic information

• Product Name: (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine
• Synonyms: (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine;2-(2-chloranyl-5-nitro-pyridin-4-yl)-N,N-diMethyl-ethenaMine;[2-(2-Chloro-5-nitropyridin-4-yl)vinyl]diMethylaMine;1. (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-dimethylethenamine;2-(2-chloro-5-nitropyridin-4-yl)-N,N-dimethylethenamine
• CAS NO: 142078-36-2
• Molecular Formula: C₉H₁₀ClN₃O₂
• Molecular Weight: 227.6476
• Mol File: 142078-36-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine(142078-36-2)
• EPA Substance Registry System: (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine(142078-36-2)

Safety Data

• Hazardous Substances Data: 142078-36-2(Hazardous Substances Data)

Usage

Uses

Used in Synthetic Chemistry:
(E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine is used as a key intermediate in the synthesis of various complex organic molecules. Its unique structure and functional groups make it a valuable building block for creating new compounds with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine is employed as a potential candidate for the development of new pharmaceuticals. Its biological activity and structural features may contribute to the design of novel drugs with therapeutic properties.
Used in Coordination Chemistry:
(E)-2-(2-chloro-5-nitropyridin-4-yl)-N,N-diMethylethenaMine is used as a ligand in coordination chemistry, where it can form complexes with metal ions. These complexes may exhibit unique properties and applications, such as in catalysis or as potential therapeutic agents.

Upstream product

• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 271-29-4 6-azaindole 
• 131084-55-4 5-chloro-1H-pyrrolo [2,3-c]pyridine 
• 1167056-96-3 3-bromo-5-chloro-1H-pyrrolo[2,3-c]pyridine 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

ISOTOPICALLY LABELED BIARYL UREA COMPOUNDS

The present invention is directed to isotopically labeled biaryl urea compounds which possess high affinity to neurofibrillary tangles (NFTs), and thus are useful to determine the amount and distribution of NFTs in brain. The isotopically labeled biaryl urea compounds may also be useful as PET tracers and in competition assays to identify other compounds that may serve as PET tracers.

NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY

The present invention relates to a compound of formula I: wherein: R1 is C1-6 alkyl, C3-8 cycloalkyl, aryl, heterocyclyl, or -COR1x, where the C1-6 alkyl, C3-8 cycloalkyl, aryl, and heterocyclyl may be substituted; and R1x is C3-8 cycloalkyl, aryl, or heterocyclyl, any of which may be substituted; R2, R3, R4, R5, R6, and R7 are each independently hydrogen, halogen, C1-6 alkyl, or aryl, where the C1-6 alkyl or aryl may be substituted; R8 is hydrogen, C1-6 alkyl, aryl, or heterocyclyl, any of which may be substituted; or a pharmaceutically acceptable salt or ester thereof.

MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)

The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.