142137-17-5

Basic information

• Product Name: 3-BROMO-5-PHENYLPYRIDINE
• Synonyms: 3-BROMO-5-PHENYLPYRIDINE;Pyridine, 3-broMo-5-phenyl-;3-BROMO-5-PHENYLPYRIDI
• CAS NO: 142137-17-5
• Molecular Formula: C₁₁H₈BrN
• Molecular Weight: 234.09
• Product Categories: Halides;Pyridines
• Mol File: 142137-17-5.mol

Chemical Properties

• Melting Point: 46.0 to 50.0 °C
• Boiling Point: 101°C(lit.)
• Flash Point: 140.3 °C
• Appearance: /
• Density: 1.426 g/cm³
• Vapor Pressure: 0.00124mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-BROMO-5-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-PHENYLPYRIDINE(142137-17-5)
• EPA Substance Registry System: 3-BROMO-5-PHENYLPYRIDINE(142137-17-5)

Safety Data

• Hazardous Substances Data: 142137-17-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
3-Bromo-5-phenylpyridine is used as a building block or intermediate in the synthesis of various complex organic molecules. Its unique structure allows it to be a valuable component in the creation of new compounds with potential applications in different industries.
Used in Pharmaceutical Development:
3-Bromo-5-phenylpyridine is used as a potential drug molecule or a precursor in the development of new pharmaceuticals. Its structure may contribute to the design of novel therapeutic agents, particularly in the fields of medicinal chemistry and drug discovery.
Used in Catalyst Design:
3-Bromo-5-phenylpyridine is used as a catalyst or a catalyst precursor in various chemical reactions. Its presence can enhance the rate and efficiency of these reactions, making it a valuable tool in the field of catalysis.
Used in Material Science:
3-Bromo-5-phenylpyridine is used in the development of new materials with specific properties, such as electronic, optical, or magnetic characteristics. Its incorporation into these materials can lead to advancements in areas like nanotechnology, electronics, and photonics.
Used in Research and Academic Studies:
3-Bromo-5-phenylpyridine is used as a research compound in academic studies and scientific experiments. Its unique properties and reactivity make it an interesting subject for investigation, potentially leading to new discoveries and insights in the fields of chemistry and related disciplines.

InChI:InChI=1/C11H8BrN/c12-11-6-10(7-13-8-11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 110-71-4 1,2-dimethoxyethane 
• 497-19-8 sodium carbonate 
• 13535-01-8 3-amino-5-bromopyridine 
• 73183-34-3 bis(pinacol)diborane 
• 603-33-8 triphenylbismuthane 
• 1008-88-4 3-phenylpyridine 

Downstream Products

• 223796-38-1 1-(5-phenyl-pyridin-3-yl)-homopiperazine 
• 614751-57-4 2-(5-phenyl-pyridin-3-yl)-9-aza-bicyclo[4.2.1]non-2-ene-9-carboxylic acid vinyl ester 
• 212332-43-9 (E)-4-[3-(5-phenylpyridin)yl]-3-buten-1-ol 
• 850991-38-7 (5-phenylpyridin-3-yl)boronic acid 
• 1050646-68-8 3-(6-methoxynaphthalen-2-yl)-5-phenylpyridine 
• 92-07-9 3,5-diphenylpyridine 
• 1593884-60-6 1-acetyl-5-(5-phenylpyridin-3-yl)-2,3-dihydro-1H-indole 
• 1008-88-4 3-phenylpyridine 
• 1404367-02-7 9-fluoro-1-methyl-7-(5-phenyl-pyridin-3-yl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline 
• 31676-55-8 5-phenylpyridin-3-ol 
• 1194450-14-0 8-(5-phenylpyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]-quinolin-4-one 

Relevant articles and documents

New sulfone-based electron-transport materials with high triplet energy for highly efficient blue phosphorescent organic light-emitting diodes

A series of new electron transport materials, which combines a diphenylsulfone core with different electron withdrawing end groups, has been synthesized, characterized, and found to exhibit high triplet energy (ET > 2.8 eV) for use in phosphorescent organic light emitting diodes (PhOLEDs). The new materials, including 3,3′-(4,4′-sulfonylbis(4,1-phenylene))dipyridine (SPDP), 5,5′-(4,4′-sulfonylbis(4,1-phenylene)) bis(3-phenylpyridine) (SPPP), and 3,3′-(4,4′-sulfonylbis(4,1-phenylene))diquinoline (SPDQ) had wide band gaps (3.6-3.8 eV) and LUMO levels of -2.4 to -2.7 eV. The triplet energy measured from phosphorescence spectra at 77 K varied from 2.53 eV for SPDQ and 2.81 eV for SPPP to 2.90 eV for SPDP, which are in good agreement with density functional theory calculated values. High performance blue PhOLEDs using the sulfone-based materials are exemplified by devices containing a poly(N-vinylcarbazole) host and SPDP electron transport layer, which had a high quantum efficiency (19.6%) and a high current efficiency (33.6 cd A-1) even at very high luminances (4500 cd m-2). These results demonstrate that sulfone-based molecules are promising electron transport materials for application in developing highly efficient phosphorescent OLEDs.

Method for preparing m-position functionalized pyridine compound

The method comprises S1, preparation 1, 4 -dihydropyridine: in a glove box filled with nitrogen, a catalyst is sequentially added into the reaction bottle. The solvents, such as borane and pyridine were stirred, stirred, at 40 - 110 °C, and reacted 5 - 12

METHOD OF PRODUCING HALOGEN COMPOUND

PROBLEM TO BE SOLVED: To provide a method of efficiently producing an aromatic compound including a halogen group of interest. SOLUTION: A method of producing a halogen compound represented by the specified general formula (1) comprises reacting a compound represented by the specified general formula (2) with a compound represented by the specified general formula (3) in the presence of a transition metal compound, a phosphine compound being 1,1'-bis(diphenylphosphino)ferrocene or 4,5'-bis(diphenylphosphino)-9,9'-dimethylxanthene, and a base. (In the formula, Ar1 and Ar2 represent organic groups; X represents a halogen group; Z represents a halogen group different than X; m represents an integer greater than or equal to 0; p represents an integer greater than or equal to 1; and each R represents a hydrogen atom, alkyl group or phenyl group, where the two R's may be linked together to form a ring.) SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

An electroluminescent compound and an electroluminescent device comprising the same

The present invention relates to an organic light emitting compound represented by chemical formula 1 and an organic electroluminescent device including the same, and the organic light emitting compound according to the present invention has excellent luminous efficiency and material lifetime properties, and thus, the organic electroluminescent device having excellent luminous efficiency while having power efficiency and long durability can be manufactured. Chemical formula 1.

C2-Alkenylation of N-heteroaromatic compounds: Via Br?nsted acid catalysis

Substituted heteroaromatic compounds, especially those based on pyridine, hold a privileged position within drug discovery and medicinal chemistry. However, functionalisation of the C2 position of 6-membered heteroarenes is challenging because of (a) the difficulties of installing a halogen at this site and (b) the instability of C2 heteroaryl-metal reagents. Here we show that C2-alkenylated heteroaromatics can be accessed by simple Br?nsted acid catalysed union of diverse heteroarene N-oxides with alkenes. The approach is notable because (a) it is operationally simple, (b) the Br?nsted acid catalyst is cheap, non-toxic and sustainable, (c) the N-oxide activator disappears during the reaction, and (d) water is the sole stoichiometric byproduct of the process. The new protocol offers orthogonal functional group tolerance to metal-catalysed methods and can be integrated easily into synthetic sequences to provide polyfunctionalised targets. In broader terms, this study demonstrates how classical organic reactivity can still be used to provide solutions to contemporary synthetic challenges that might otherwise be approached using transition metal catalysis.

Triarylbismuthanes as threefold aryl-transfer reagents in regioselective cross-coupling reactions with bromopyridines and quinolines

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalysed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalysed conditions. Copyright

Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor

We introduce the term 'silent agonists' to describe ligands that can place the α7 nicotinic acetylcholine receptor (nAChR) into a desensitized state with little or no apparent activation of the ion channel, forming a complex that can subsequently generate

Synthesis of pinacol arylboronates from aromatic amines: A metal-free transformation

A metal-free borylation process based on Sandmeyer-type transformation using arylamines derivatives as the substrates has been developed. Through optimization of the reaction conditions, this novel conversion can be successfully applied to a wide range of aromatic amines, affording borylation products in moderate to good yields. Various functionalized arylboronates, which are difficult to access by other methods, can be easily obtained with this metal-free transformation. Moreover, this transformation can be followed by Suzuki-Miyaura cross-coupling without purification of the borylation products, which enhances the practical usefulness of this method. A possible reaction mechanism involving radical species has been proposed.

POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

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Theramutein modulators

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